Vacation rentals in Defiance

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Top-rated vacation rentals in Defiance

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Guest favorite

Tiny home in Pacific

4.96 out of 5 average rating, 214 reviews

Route 66 Railroad Shanty, a cozy artsy small space

This 536 s.f. house, believed to have once been a sleeping shanty for railroad crews switching shifts for the night. Fully renovated and updated in 2021 by a local artist, you will find custom metal art throughout, granite countertops and a very warm cabin feel featuring a kitchen and bathroom finished with locally sourced Missouri dark red cedar, 10 minutes from six flags, Purina farms 15 min from hidden valley and 45 min from downtown this place is in a great location and will not disappoint!

Guest favorite

Cottage in Eureka

4.93 out of 5 average rating, 280 reviews

Beautiful Cottage on Large Private Lot

This lovely rural cottage is nestled back in the woods on its very own private acre of land. It offers guests a beautiful getaway experience while walking the property or hanging out on the large covered front porch; while at the same time being just a 7 minute drive from downtown Eureka with its many delicious restaurants and adorable boutiques. If Six Flags is your goal you can enjoy the hustle bustle of the amusement park during the day and relax after a 15 minute drive back to the cottage.

Guest favorite

Home in Augusta

4.99 out of 5 average rating, 243 reviews

Katy Trail Farmhouse - 3 bd/2.5 bath - Amazing!

DIRECTLY ON THE KATY TRAIL! Quaint 1943 farmhouse on 7 private acres in Missouri wine country - halfway between Klondike Park & the town of Augusta. Loads of farmhouse charm w/ the amenities & comforts of home. Spacious & well-appointed, 3 bedrms/2.5 baths. Walk-in/out or bike-in/out to KATY trail -- the location is perfect. Enjoy a sunset dinner & live music at one of the many wineries – or relax on one of the two screened-in porches & clear your mind. No other place like it in Augusta!

Guest favorite

Home in Saint Charles

4.98 out of 5 average rating, 554 reviews

301 Guesthouse- Historic Main street-Katy Trail

Our 301 Guest House is new and completely remodeled in 2018! It’s ideal for one or two people with beautiful furnishings, great queen bed, lots of amenities, full kitchen, with big back yard and patio to enjoy outdoors too! Cable and FAST WiFi! Enjoy light Breakfast! BEST location, Great events year round within walking distance, with being only about 2 blocks from S. Main St, where there are about 100 gift shops n restaurants! Katy Trail is so close, with Spring, Summer, Fall and Xmas events!

Guest favorite

Chalet in Innsbrook

4.97 out of 5 average rating, 124 reviews

Modern Lakefront Chalet at Innsbrook

Updated modern 2 bed 2 bath lakefront chalet located within the Innsbrook Resort. Enjoy private access and of the small Lake Powderhorn. This stylish chalet has 2 bedrooms each with a queen size bed. The open living room has a large sectional and a separate full size couch. The updated kitchen includes a stove, dishwasher, and a laundry unit. As part of the Innsbrook resort, you'll also have access to the many amenities, including golf course, swimming complex, various lakes, trails, etc.

Guest favorite

Cabin in Innsbrook

4.94 out of 5 average rating, 173 reviews

Squirrel Run at Innsbrook Resort

WINTER ---> NOV-MAR: 4 -wheel drive car is recommended. In heavy snow, the cabin is deep in the woods & services would not be able to plow you out immediately. NO PARTIES. We have a 8 person occupancy. This includes holidays. Squirrel Run is nestled on 3 acres in a secluded wooded setting within the Innsbrook Resort Community. This 2-bedroom, 1-bathroom home sleeps 8 and offers everything from hiking, canoeing, swimming, or lounging around the firepit. More details on IG @squirrel_run_ibk

Guest favorite

Cabin in Defiance

4.94 out of 5 average rating, 122 reviews

Hillside Cabin on 43 Acres w/ Private Lake & View!

Free from modern distractions, this 1-bedroom, 1-bath cabin in the heart of wine country is the perfect place to unplug and reconnect with nature! Immersed in lush woodlands, the Defiance vacation rental comes with all the amenities needed for a peaceful retreat, including a fishing lake, resident horses, and a fully equipped kitchen. Watch the sunrise over the hills from the porch swing before venturing off to Katy Trail, and later, head to Chandler Hill Vineyards located just minutes away!

Superhost

Tiny home in Pacific

4.9 out of 5 average rating, 565 reviews

Route 66 Cozy Cottage

* Fast Wifi (Spectrum) * Keypad entry (no keys to keep track of) * Private driveway by the front door for easy access to carry luggage in and out * Huge yard for dogs, kids or even adults to play * Lovely outdoor patio with plenty of comfortable seating and beautiful landscaping * For the kiddos- fun, colorful plastic dinnerware, toys, books, puzzles, and games (puzzles and games for adults too) * Essentials for your furbabies as well - treats, leashes, food & water bowls, waste bags, towels

Guest favorite

Home in Gray Summit

4.88 out of 5 average rating, 140 reviews

Sunset Mountain Privacy

9 rooms on the main floor with private entrance, kitchen, and covered deck are all yours in this shared property. Host stays in lower level and the only places shared are the laundry room & outside. Great for families and dog owners attending Purina Farms. I allow birthday & graduation celebrations, baby & bridal showers, meetings & conferences, classes & reunions with a maximum capacity of 25 people or 9 vehicles. Let me help make your special occasion one to remember.

Guest favorite

Guesthouse in Marthasville

4.96 out of 5 average rating, 250 reviews

Hazel's House by the Katy Trail

In the heart of Missouri Wine Country. Within walking distance of the Katy Trail and Lake Creek Winery. Many wineries within a 25-30 minute drive. Enjoy a weekend getaway in a 2 bed 1 bath home. Hazel's House is clean, comfortable and private overnight accommodations. We are not a bed and breakfast, no food included, but there is coffee. Please make sure the location is suitable. We are located out in the country and the internet can be spotty.

Guest favorite

Home in Dittmer

4.95 out of 5 average rating, 427 reviews

Honeymoon Suite Camp Skullbone In The Woods

Romantic quiet cozy chalet for two! Vintage décor with all the modern amenities of home. Relax inside to unwind, kick back and watch a movie, surf the web via free wi-fi, curl up with a good book, open up a board game for a friendly challenge or share a drink with that special someone. Want some fresh country air? Lace-up those hiking boots and take like Camp Skullbones. . Enjoy the stars on the intimate deck with the glow from the gas fire pit.

Guest favorite

Farm stay in Lake Saint Louis

4.92 out of 5 average rating, 213 reviews

Updated Farmhouse 2 bdrm 2 bd 2 acres

Updated Farm House on 2 acres, 2 bedrm with 2 queen beds, 1 full size bed, fully equipped kitchen, living room, smart TV with roku, wifi, a full bathroom with double sinks and laundry, this house is a duplex, with 2 separate units, the upstairs is for Airbnb guest, the lower unit has a tenant, each unit has its own space and entrance. located in a central area, just 25 minutes from the St. Louis Airport. Lots of shops, parks, businesses.

Vacation rentals for every style

Get the amount of space that is right for you

Popular amenities for Defiance vacation rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

Stay near Defiance's top sights

Montelle Winery18 locals recommend

Historic Daniel Boone Home15 locals recommend

Chandler Hill Vineyards15 locals recommend

Klondike Park14 locals recommend

Wine Country Gardens11 locals recommend

Noboleis Vineyards10 locals recommend

Other great vacation rentals in Defiance

Guest favorite

Home in Villa Ridge

4.94 out of 5 average rating, 72 reviews

Serenity Valley

Guest favorite

Home in Augusta

5 out of 5 average rating, 71 reviews

Central Luxe 5br Home | Hot Tub & Views | 🥂 🍷

Guest favorite

Guest suite in Union

4.94 out of 5 average rating, 89 reviews

TJ’s Country Getaway *Dog Friendly*

Guest favorite

Home in St. Peters

4.94 out of 5 average rating, 52 reviews

Family Friendly Home Near Parks and Dining

Guest favorite

Home in Gray Summit

4.97 out of 5 average rating, 32 reviews

Cozy pet friendly home with fenced yard.

Guest favorite

Home in Gray Summit

4.92 out of 5 average rating, 79 reviews

Pet Friendly - Fenced Yard - <1 mile from Purina

Guest favorite

Farm stay in New Haven

4.97 out of 5 average rating, 71 reviews

The Round Room Tower at Moy Mell Farm

Guest favorite

Home in Augusta

5 out of 5 average rating, 21 reviews

Welcome to the Owls Nest!

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Quick stats about vacation rentals in Defiance

Total rentals
10 properties
Nightly prices starting at
$70 before taxes and fees
Total number of reviews
680 reviews
Wifi availability
10 properties include access to wifi
Popular amenities
Kitchen, Wifi, and Pool
Local attractions
August A. Busch. Memorial Conservation Area, Chandler Hill Vineyards, and Weldon Spring Conservation Area

Vacation rentals in Defiance

Top-rated vacation rentals in Defiance

Tiny home in Pacific

Cottage in Eureka

Home in Augusta

Home in Saint Charles

Chalet in Innsbrook

Cabin in Innsbrook

Cabin in Defiance

Tiny home in Pacific

Home in Gray Summit

Guesthouse in Marthasville

Home in Dittmer

Farm stay in Lake Saint Louis

Vacation rentals for every style

Hotels

Unique stays

Homes

Popular amenities for Defiance vacation rentals

Stay near Defiance's top sights

Other great vacation rentals in Defiance

Home in Villa Ridge

Home in Augusta

Guest suite in Union

Home in St. Peters

Home in Gray Summit

Home in Gray Summit

Farm stay in New Haven

Home in Augusta

Quick stats about vacation rentals in Defiance

Total rentals

Nightly prices starting at

Total number of reviews

Wifi availability

Popular amenities

Local attractions

Destinations to explore