We’re sorry, some parts of the Airbnb website don’t work properly without JavaScript enabled.

Airbnb your place

James Island vacation rentals

Book unique vacation rentals, houses, and more on Airbnb

Top-rated vacation rentals in James Island

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Villa in Isle of Palms

5 out of 5 average rating, 3 reviews

New Listing! Lagoon Villa 34 - Top Floor Serenity!

Professionally managed by Deserving Vacations! Discover the charm of Isle of Palms at our top-floor Lagoon Villa 34! This cozy 2BR/2BA villa is perfect for small families or friends. Unwind in comfort after a day of island exploration! Super quick and simple 5 minute walk to the beach! Each bedroom has a full en suite bathroom and private balcony. This vacation rental provides easy access to all Wild Dunes shops, restaurants, spa, golf courses and biking/walking paths. Would love to host you!

Cottage in Kiawah Island

5 out of 5 average rating, 11 reviews

Incredible riverfront, gorgeous, renovated cottage

perfect views, popular area Exceptional River views can be enjoyed from this recently renovated, three bedrooms, two bath cottage in Inlet Cove's gated community. 43 Sunlet Bend has new hardwood floors throughout the living areas. It has three bedrooms with one king-size bed, one queen, and two twins which can accommodate up to six guests. This cottage is the ideal place for a family vacation. The enclosed porch at the back of the rental is great for watching dolphins play or the gorgeous ...

Home in Isle of Palms

4.93 out of 5 average rating, 91 reviews

Steps from the beach: extraordinary home and yard

-The beach a few steps away: wander down just 300ft and you will feel sand on your toes or just relax in the hot tub -Outdoor living: Achieving the indoor/outdoor lifestyle isn't exactly easy but this house does it! Perfect for lounging, lazy afternoons and outdoor dinner. In the colder month enjoy the fire pit, smores time anyone? - Additional attached apartment can be added for more space and comfort -Idyllic family escape: It displays charm, character, and luxurious comforts for all ages

Home in Edisto Island

4.99 out of 5 average rating, 81 reviews

Marshfront Villa In The Trees - Near Beach & Bay

"The most unique and relaxing place to enjoy the tranquility and experience of Edisto. We did not want to leave" - Sambo Nestled atop 360-degree marsh views, you'll be immersed in the exotic natural beauty and wildlife of the Edisto sea island. Hear the waves crashing at the beach from the front porch and watch the marsh tides rise and fall from your choice of the many porches. "Nature with luxury.. our group loved floating from the house out to the inlet for private beach days" - JP

Home in Mount Pleasant

4.87 out of 5 average rating, 458 reviews

Beach+Downtown ★Walkable Old Village Luxury Style2

Best of Both worlds--3 minutes to Downtown Charleston & Sullivan's Island Beach! Mt Pleasant is Rated the Best Place to Live in SC! Enjoy Downtown Mt Pleasant Amenities. Old Mt. Pleasant in a Marsh-front Community. Beautiful 100 year-old Oak Trees! Walk to Shem Creek Restaurants & Marina, Steps to Old Village, Grocery stores, coffee shops, shopping, Red Drum Gastro Pub, New Mt P. Farmers Market. Relax in wonderful large private backyard under tree canopy. STR ST240049 BL: 20123990

Condo in Edisto Island

4.91 out of 5 average rating, 148 reviews

A Room With a View. Recently Renovated Condo!

If you are looking for a comfortable, easy to access, quiet getaway, then you have found it. This pristine, recently refurbished studio condo has everything you need. Huge 12x12 deck offer additional outdoor space for relaxing. On the 9th green of the Plantation Course. Short walk or bike ride to the beach. You will love the location and the space. Very close to The Waters Edge coffee shop, Ella & Ollies, bike rentals. Sister property to All Inn on Edisto and Cozy Edisto Condo.

Home in Isle of Palms

4.9 out of 5 average rating, 114 reviews

Amazing Location, across the st. from the beach!

Located directly across the st. from the beach, w/public access! Fully fenced, pet friendly. 4 bd - sleeps 10 comfortably, 2.5 bths. Bright open airy design. Huge living room w/high vaulted ceilings. Eat-in kitchen & newer appliances. Formal dining rm w/lots of glass & great views. 3 front porches-1 screened. 3 Decks. French doors in up. bds lead to outdoor sitting areas. Close to awesome restaurants, shopping, food stores & so much more! ONLY WEEK LONG MIN STAYS IN SUMMER

Home in Charleston

4.98 out of 5 average rating, 132 reviews

❤️ of Charleston - Luxurious & Rustic -Near King!

Completely Renovated House - 1block from King Street! (Brand New Listing! - Rare Find!) * 3 bedrooms +2 full bunk beds & 2 full bathrooms * Brand new Construction - Heavily insulated and quiet inside! * High End Kitchen! * Walk Score 98 ('Very Walkable') * 1 Block From King Street * Private Outdoor Piazza + Outdoor Terrace * Off Street Parking for 2 vehicles * Onsite washer's & dryer's * Safe neighborhood in awesome location - near all the best restaurants and bars!

Home in Isle of Palms

4.97 out of 5 average rating, 101 reviews

Luxury Coastal Cottage With Pool

Experience Life in The Lowcountry! Our Coastal Cottage has luxury finishes, a gourmet kitchen, spacious bedrooms, and the new pool installed Spring of 2022 is ideal for discerning travelers of all ages. We pride ourselves on making sure your vacation time is special. Isle of Palms offers a premier beach vacation experience with pleasant beaches and delightful restaurants. We are a 5-minute walk to the beach on a quiet residential street away from the crowds.

Home in Folly Beach

4.93 out of 5 average rating, 238 reviews

Folly Vacation 204 Getaway, Relax & Unwind

This unique Spanish-style 2 bedroom, 1 1/2 bath beach house is in a quiet residential area with an easy walk to all the restaurants, shops and the ocean. Respectfully renovated to maintain its historic integrity, you’ll appreciate the mix of old and new. Dog friendly with a one-time fee of $110 per dog up to 3 nights, and $150 per dog for 4 or more nights. Fee is added once your reservation is confirmed. Rental Registration Number STR22-00313

Home in Seabrook island

4.88 out of 5 average rating, 8 reviews

Serene Top Floor Villa Under the Ancient Oaks

Relax and unwind at this private villa centrally located on a quiet street, near both the Seabrook Island Club and the private beach. CANCELLATION POLICY: Please note a cancellation processing fee of $65 will be charged for all reservations booked then cancelled irrelevant of when they are cancelled. PROFESSIONALLY LICENSED & MANAGED: Town of Seabrook Business License 2024-1217, STR Seabrook Island Permit 2024-0015

Home in Folly Beach

4.95 out of 5 average rating, 172 reviews

Lux Beach Bungalow Ocean Views Heated Pool

Luxury furnishings and linens. Stay in a home not just an Airbnb. One block to Center Street which means you are walking distance to all the shops, bars, and restaurants on the island, the pier, and across the street from Berts corner store. Relax on the beach. Shower outside. Sip cocktails on one of the porches with beach views. Grill out by the pool. Take a stroll to dinner and enjoy some live music.

Vacation rentals for every style

Get the amount of space that is right for you

Houses

A space thats all yours, with room for everyone

Apartments

Convenient locations with everyday essentials

Villas

Luxurious estates for the ultimate escape

Popular amenities for James Island vacation rentals

Free parking on premises

Laptop-friendly workspace

Other great vacation rentals in James Island

Home in Edisto Island

4.94 out of 5 average rating, 16 reviews

Pelican Point-King Cotton Villas - Beach/Golf/Pool

Condo in Seabrook Island

4.95 out of 5 average rating, 93 reviews

On the Beach-End Unit! Enjoy Dolphins & Sunsets!

Home in Johns Island

5 out of 5 average rating, 18 reviews

Seabrook Lagoon Views

Guesthouse in Charleston

5 out of 5 average rating, 3 reviews

Private 2 bedroom cottage near the beach

Home in Johns Island

5 out of 5 average rating, 3 reviews

Coastal Retreat, Pool, Steps from Beach, Golf!!!

Home in North Charleston

5 out of 5 average rating, 34 reviews

Charleston - Pool - Near Airport, Downtown & Beach

Rental unit in Johns Island

4.93 out of 5 average rating, 14 reviews

164 High Hammock Villa

Home in Isle of Palms

4.93 out of 5 average rating, 58 reviews

Coastal Escape: island Oasis with Pool + rooftop

Destinations to explore