Vacation rentals in Des Moines County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Des Moines County

Guests agree: these stays are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Rental unit in Burlington

4.84 out of 5 average rating, 51 reviews

Relaxing 1 bedroom apartment Sleeps 2, 1st floor

This comfortable space has all the amenities of one's own home. Feel free to use the furnished kitchen, soak in the shower/tub. Soaps and towels provided. Or just relax in the sun filled living room. wifi and 65 inch smart TV. Blocks away from shopping, dining, entertainment, Mississippi River front and everything Burlington has to offer. Take a short walk (1 block) to a stunning overlook at Mosquito Park, the park offers a stunning view of the Mississippi as it flows into the Burlington area.

Guest favorite

Home in Burlington

5 out of 5 average rating, 32 reviews

The Happy, Hippie Homestead 3BRM Sleeps up to 10

Located minutes from the Mississippi riverfront and Burlington's Historic Downtown, this beautiful old home is spacious and perfect for hosting small intimate gatherings with family and friends. A stay at this property offers its guest a homesteading experience that may include fresh eggs from our chickens, fresh fruit and veggies from our garden, and baked goods like my famous chocolate chip cookies, artisan style homemade breads and pastries. All dependent upon availability and time of year.

Guest favorite

Townhouse in Burlington

4.97 out of 5 average rating, 30 reviews

Mosquito Park Condo

Have fun with the whole family at this stylish 1890 building. There's a park that overlooks the Mississippi. And for the musically inclined there is a piano. Play your heart out! And it's just a short walk downtown. Where there's lots of great restaurants and cool shops. Rates are set by AirBnB. I offer weekly and monthly stays discounts. Allana is my cleaner. She does a wonderful job preparing the place for guests. I pay her a living wage. Which you can see in the listing cost breakdown.

Guest favorite

Home in Burlington

4.86 out of 5 average rating, 95 reviews

Cheerful Bungalow with original woodwork

This home features original woodwork, charm and character- great open front porch and back porch, living room, dining room and eat in kitchen, 3 upper level bedrooms. Full basement with laundry plus shower and stool. There is a desk for when you need a quick catch on your laptop or ipad. Relax on the porch or in the original metal kitchen with glass panels and enamel farmer sink. 1 large bedroom with queen bed and two small bedrooms with double bed Basic cable and WIFI included

Guest favorite

Home in Sperry

4.89 out of 5 average rating, 9 reviews

Porches and Pines Farmhouse

Room for All! With three fully furnished levels, Porches & Pines can comfortably sleep up to 20 guests. We love families and have worked hard to make this the perfect place to bring the whole gang for a pile of fun! Located in rural Sperry, Iowa, this is the perfect country retreat. Situated on the edge of a Christmas tree farm, you will enjoy the peaceful environment on the 5 Porches and the sound of the wind whispering through the mighty Pines.

Guest favorite

Loft in Burlington

4.99 out of 5 average rating, 232 reviews

The Peacock Loft / Spacious Artistic Loft

Welcome to The Peacock Loft! This space is a reflection of my passion for design, color, and attention to beautiful details. Every corner is filled with art, custom designs, travel treasures, creative books, vintage decor, and boho charm. Set in a charming historic building with modern updates, it’s just a few blocks away from the nostalgic Downtown Burlington, Iowa. We’ve equipped the loft with all the amenities you need for a comfortable stay.

Guest favorite

Cabin in Oquawka

5 out of 5 average rating, 31 reviews

The Shoreline Shanty

Take it easy at this unique and tranquil getaway. This cabin offers a outstanding view overlooking the river. You will find you are very close to everything Oquawka has to offer, restaurants, bars, parks, laundry mat, grocery store, car wash, & churches. ( FOR THOSE OF YOU WHO ENJOY BOATING ON THE MISSISSIPPI RIVER ARE LOCAL BOAT CLUB OFFERS BOAT SLIPS FOR RENT AND FREE TRAILER PARKING DURING YOUR STAY, UPON BOOKING DETAILS WILL BE PROVIDED)

Guest favorite

Home in Burlington

5 out of 5 average rating, 27 reviews

Beautiful Brick Townhouse 3 blocks from downtown

Newly remodeled, this house keeps the charm of the 1880’s brick it was built with while giving all the modern convenience you need. The first floor boasts granite countertops, beautiful brick walls, and a spacious open floor plan. The second floor has 3 bedrooms and 2 full bathrooms, so you can bring the whole family to visit. This location is just blocks from downtown and 3 short miles from the Burlington Rec Plex.

Guest favorite

Home in Burlington

4.99 out of 5 average rating, 172 reviews

Snake Alley Inn, a one-of-a-kind location.

Snake Alley Inn, a Victorian home nestled high on the hill on Burlington's famous Snake Alley. This 1894 landmark brick-paved street, was once recognized by Ripley's Believe It or Not as the Crookedest Street in the World. Built in 1860 this historic home is adorned with 3 bedrooms and 2 full baths. Located within walking distance to Burlington's dynamic downtown, where you'll find many shops, pubs and eateries.

Guest favorite

Home in Burlington

4.9 out of 5 average rating, 120 reviews

The Fleetwood Bungalow with Dreamy Porch

Welcome to The Fleetwood Inn! A charming, cozy one-bedroom bungalow in the heart of Burlington, Iowa. Right between our bustling business district and our nostalgic downtown, this little house has vast character. My favorite feature is all the original built-ins and beams. You will love the Western American inspiration and vintage finds, modern touches throughout, and dreamy details in every corner.

Guest favorite

Home in Oquawka

4.91 out of 5 average rating, 11 reviews

Warm & inviting 3 BR/4 beds, pet friendly home

Get the old with the new. Original hardwood floors, and antique furniture with all the modern amenities. 10 min to the Barn venue in Biggsville, IL, 15 to Burlington, IA, Snake Alley Ripleys believe it or not unbelievably crooked road. 5 min to Allaman Covered Bridge. 15 min to Monmouth, IL Bring the whole family to this great place with lots of room for fun.

Guest favorite

Rental unit in Burlington

4.94 out of 5 average rating, 112 reviews

Riverview Upstairs Apartment

Upper level duplex located near downtown Burlington. We are within walking distance from Dairy Queen and Jerry’s Main Lunch (our favorite breakfast!) Only 1.5 miles to downtown shopping, riverfront, entertainment and restaurants. Private balcony with river views, private laundry and pet waste stations. Set next to a large open lot for pets and outdoor activities.