Family-friendly vacation rentals in Little Italy, San Diego

Find and book unique family-friendly homes on Airbnb

Top-rated family-friendly rentals in Little Italy, San Diego

Guests agree: these family-friendly homes are highly rated for location, cleanliness, and more.

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Guest favorite

Loft in Downtown San Diego

4.86 out of 5 average rating, 712 reviews

Sunny, Open 2 Story Apt Downtown w/ Parking

Our Spacious 2 Story, Beautifully Decorated Apt is the Perfect Home Away From Home for Families, Couples, Digital Nomad, or Solo Traveler Looking for a Comfortable & Convenient Place to Stay. Located in One of the Most Vibrant Neighborhoods in SD Little Italy is Known For its Restaurants, Cafes, & Local Shops. So Many Attractions! the Waterfront Park, CRSSD Festival, USS Midway Museum., Balboa Park, Petco Park, The Convention Center, Running/Bike Paths, The County Building. 1 Free Parking Spot

Guest favorite

Guesthouse in Kensington

4.97 out of 5 average rating, 550 reviews

Central & Serene Secret Garden Guesthouse

My cozy & stylish Garden Guesthouse features colorful decor that gives a fun, relaxed vibe. Relax in style inside or outside in my peaceful garden w a cup of coffee, or glass of wine. I love to say a hi to my guests yet your privacy is #1. Reach me via Airbnb app if I can help! Kensington is a central, 1920’s historic neighborhood w shops & great local eateries. Close to downtown, Gaslamp, Zoo, airport, beaches, Balboa Park. Bus stop, & trolley nearby. Reserved off street parking space too!

Guest favorite

Guesthouse in North Park

4.96 out of 5 average rating, 226 reviews

North Park, San Diego's Best At Your Doorstep

Incomparable location, privacy, quality and unique experiences await the discerning traveler. Walk to dozens of renown restaurants, coffee shops, micro-breweries, bars, art galleries, unique shops, stores and world famous attractions from your exceptional detached studio suite. Come see why Forbes Magazine, Time Magazine, The New York Times, The LA Times and The San Diego Union Tribune recently acclaimed North Park as San Diego's Favorite Neighborhood, The Hippest In The Nation and Smokin' Hot!

Guest favorite

Rental unit in Mission Hills

4.86 out of 5 average rating, 283 reviews

Spacious apartment, old world charm

Our open-space apartment is full of charm and character. From the Spanish-tiled private entry to the footed tub shower, you will experience a unique feeling. Enjoy the nearby vibrant restaurant scene as well as the rooftop deck with its harbor view! The ceilings are low in a couple spots and could be a challenge for folks who are especially tall. My boyfriend is 6'4" and has learned to adapt! It may be something to consider. House noises travel in this old home, so it can be a factor for some.

Guest favorite

Guest suite in San Diego

4.98 out of 5 average rating, 450 reviews

Super clean & private studio retreat.

We call our place Casita Pacifica (Peaceful Little House) as this suite is a mellow and relaxing retreat, yet in a San Diego suburb only 10-20 minutes from everything. Sadly, we no longer host peacocks, but our space is decorated in memory of their majestic energy. Our standards are high when we travel, so we created a suite that we'd love to stay in ourselves: stocked with goodies, things to do, recommendations, privacy, comfort & above all - cleanliness. WE FOLLOW CDC CLEANING GUIDELINES.

Guest favorite

Guesthouse in Sherman Heights

4.96 out of 5 average rating, 513 reviews

Romantic Private Garden Studio Near Downtown

A magical private garden surrounds a tiny studio (240 sq ft) with kitchenette in historic residential district, 10 blocks to East Village and Petco BallPark, near Gaslamp Quarter, and one mile to Convention Center and downtown. Easy access to freeways, very close to Balboa Park, San Diego Zoo, and Coronado Island. Airport and train station less than 15 min. We offer a safe, sweet, and contemplative getaway near the city, with WiFi but no TV. One pet OK only with prior approval. 420 friendly.

Superhost

Townhouse in Downtown San Diego

4.82 out of 5 average rating, 722 reviews

BEST LOCATION in all of Little Italy & downtown!

Location, location, location! Can't get any closer to the bustling Little Italy area in downtown San Diego. San Diego's best restaurants and nightlife in your backyard. One of the only houses in all of downtown! This modern luxury home is just blocks from the waterfront and a short Uber or walk to the Gaslamp, Convention Center & San Diego Zoo! All the frills: ++ Prime location! 98/100 Walker Score rating ++ High-speed internet, Netflix & smart TV ++ A/C ++ Super Host 5-star service

Guest favorite

Guesthouse in North Park

4.93 out of 5 average rating, 480 reviews

Private Cottage in Walkable North Park w/AC

Welcome to our charming private Airbnb in vibrant North Park! Enjoy the perfect blend of comfort and convenience for your San Diego stay. Walk to restaurants, coffee shops, art galleries, wine bars, breweries, yoga studios & various boutiques. Nature lovers will adore the nearby Balboa Park with its stunning gardens and cultural attractions. Downtown, Gaslamp Quarter, beaches, and the famous San Diego Zoo are easily accessible. Book and create lasting memories in this dynamic neighborhood.

Guest favorite

Rental unit in Serra Mesa

4.98 out of 5 average rating, 428 reviews

Lovely spacious upstairs studio with private entry

You’ll love our place as its spacious, quiet, private, comfortable in a residential neighborhood. The king-size bed is extremely comfortable and we have big relaxing patio chairs on our large balcony overlooking a beautiful landscaped garden. We are centrally located to most all of San Diego's attractions and close to freeways. The famous Gaslamp, Zoo, downtown and beaches are all within 13 to 20 minute drive. The kitchen is stocked with goodies, coffee and an assortment of teas.

Guest favorite

Home in Downtown San Diego

4.98 out of 5 average rating, 248 reviews

Downtown View - 2 Story House Next to Little Italy

Two story house with 2 living rooms; 3 blocks to Little Italy restaurants, bars, & shops. Near Balboa Park, San Diego Zoo, Gaslamp, Waterfront Park & the Harbor. Museums, restaurants, theaters & nature are all nearby. Located in historic Bankers Hill, next to Interstate 5, near the airport and city center. With 2 living rooms, my house is perfect for travelers needing separate space. One parking spot is available. Extra large vehicles will have to park on the street.

Guest favorite

Loft in Downtown San Diego

4.96 out of 5 average rating, 658 reviews

Room A at The Dutra Inn - Little Italy

“There’s a strange and wonderful energy on top of The Dutra. I imagine the ghosts of pirates past making their way up from San Diego Bay, and cosmic cowboys riding in from the Tijuana night. Room A is a meeting place. It’s actually where we first met. When you look up from the street below, you can see the rows of whiskey bottles.* You might even spot Pappy Van Winkle himself winking down at you. But from Room A, you can see so much more—rooftops, skyrises, and ships.

Guest favorite

Guest suite in Point Loma Peninsula

4.95 out of 5 average rating, 605 reviews

Private Hideaway, Shelter Island, Beach & Bay

Spotless studio apartment with all amenities. Relax on the private patio enjoying a panoramic view of Downtown and San Diego Bay, or get cozy in a love-seat by the outdoor Chiminea. The unit has a full kitchen and an outdoor BBQ. Private parking right out front. Quiet neighborhood, but close to Downtown, Beaches, SeaWorld and the World Famous San Diego Zoo. Walk to local restaurants, bars, Eppig brewery, bay side trails, grocery store, and sports fishing.