Guesthouse vacation rentals in Mission Bay, San Diego
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Mission Bay, San Diego
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Mission Bay, San Diego guesthouse rentals
Family-friendly guest house rentals
Guesthouse in San Diego
4.77 out of 5 average rating, 886 reviewscharming, colorful, close to beach
Guesthouse in San Diego
4.77 out of 5 average rating, 605 reviews$100-150 night--Windansea #3
Guesthouse in San Diego
4.83 out of 5 average rating, 224 reviewsPacific Beach Cottage Blocks from Beaches/La Jolla
Guesthouse in San Diego
4.97 out of 5 average rating, 255 reviewsThe Coziest Retreat in N. PB
Guesthouse in San Diego
4.97 out of 5 average rating, 512 reviewsCentral & Serene Secret Garden Guesthouse
Guesthouse in San Diego
4.82 out of 5 average rating, 361 reviewsBeach Cabin Guesthouse with Patio Deck
Guesthouse in City Heights
4.92 out of 5 average rating, 246 reviewsNorth Park Garden Studio
Guesthouse in San Diego
4.88 out of 5 average rating, 169 reviewsEco Luxury Cottage
Guest house rentals with a patio
Guesthouse in San Diego
4.92 out of 5 average rating, 155 reviewsCentral studio w/ private outdoor space & parking
Guesthouse in Mission Hills
5.0 out of 5 average rating, 114 reviewsSantorini-Inspired Cottage #1 w/ Hot Tub + Views
Guesthouse in San Diego
4.98 out of 5 average rating, 107 reviewsStunning Patio! King Bed, Walkable, Games, Parking
Guesthouse in San Diego
4.99 out of 5 average rating, 155 reviewsAdorable cottage in Talmadge
Guesthouse in La Mesa
4.98 out of 5 average rating, 256 reviewsLa Mesa Suite
Guesthouse in Lakeside
4.94 out of 5 average rating, 105 reviewsSky Mesa-Adorable Cottage on the Hill
Guesthouse in La Mesa
4.99 out of 5 average rating, 176 reviewsSDCannaBnB #1 *420 *parking *dog-friendly *hot tub
Guesthouse in San Diego
4.99 out of 5 average rating, 146 reviewsMission Hills-Entire Guest House-Center of it All
Guest house rentals with a washer and dryer
Guesthouse in Point Loma Peninsula
4.93 out of 5 average rating, 148 reviewsPoint Loma Private Apartment
Guesthouse in San Diego
4.89 out of 5 average rating, 651 reviewsSouth Mission Beach Zen-Like Studio
Guesthouse in Ocean Beach
4.89 out of 5 average rating, 286 reviewsRefurbished Indoor/Outdoor Sanctuary in Ocean Beach
Guesthouse in San Diego
4.91 out of 5 average rating, 170 reviewsBrand New Cozy Detached Casita w/AC & heat
Guesthouse in San Diego
4.99 out of 5 average rating, 134 reviewsCarrie’s North Park Casita, in Heart of San Diego
Guesthouse in San Diego
4.98 out of 5 average rating, 390 reviewsLuxurious Villa near beach
Guesthouse in San Diego
4.95 out of 5 average rating, 111 reviewsAdorable studio/private entrance/reserved parking
Guesthouse in San Diego
4.95 out of 5 average rating, 122 reviews1BR Casita in the Heart of Kensington!
Quick stats about guesthouse rentals in Mission Bay, San Diego
Total rentals
20 properties
Popular amenities
Kitchen, Wifi, and Pool
Wifi availability
20 properties include access to wifi
Rentals with dedicated workspaces
10 properties have a dedicated workspace
Total number of reviews
2.4K reviews
Nightly prices starting at
$100 before taxes and fees
Destinations to explore
- Guesthouse rentals United States
- House rentals United States
- Guesthouse rentals San Diego
- House rentals San Diego
- Guesthouse rentals San Diego
- House rentals San Diego
- House rentals California
- Guesthouse rentals California
- House rentals Palm Springs
- Guesthouse rentals Palm Springs
- Guesthouse rentals Anaheim
- House rentals Anaheim
- Family-friendly rentals Mission Bay
- Kid-friendly rentals Mission Bay
- Wheelchair accessible rentals Mission Bay
- Condo rentals Mission Bay
- Smoking-friendly rentals Mission Bay
- Pet-friendly rentals Mission Bay
- House rentals Mission Bay
- Rentals with a kayak Mission Bay
- Waterfront rentals Mission Bay
- Rentals with a fire pit Mission Bay
- Townhouse rentals Mission Bay
- Rentals with a hot tub Mission Bay
- Monthly Rentals Mission Bay
- Hotel rentals Mission Bay
- Fitness-friendly rentals Mission Bay
- Rentals with lake access Mission Bay
- Rentals with a patio Mission Bay
- Beachfront rentals Mission Bay
- Rentals with a fireplace Mission Bay
- Rentals with pools Mission Bay
- Rentals with beach access Mission Bay
- Rentals with a washer and dryer Mission Bay
- Apartment rentals Mission Bay
- Rentals with outdoor seating Mission Bay
- Bungalow rentals Mission Bay
- Cottage rentals Mission Bay
- Rentals with an EV charger Mission Bay
- House rentals San Diego County
- Guesthouse rentals San Diego County
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom