Vacation rentals in Santa Clara

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Clara

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite

Villa in Chame

4.84 out of 5 average rating, 180 reviews

Surf Relax Play Pacific Ocean View Villa

White sand, surf-able waves, or just a comfortable chill vibe to enjoy the tropical weather of Panama. Playa Caracol is about an hour and 10 minutes drive from the city. This spacious, 2 bedroom, 2 bath villa with it's Pacific Ocean front location is the perfect place for you to enjoy an unforgettable family vacation. Walk out to the beach just steps from the villa, swim in the pool next to this villa or enjoy the resort pools and amenities. Or hike the nearby mountains with a local guide.

Guest favorite

Earthen home in El Cope, Penonome

4.92 out of 5 average rating, 153 reviews

Beautiful Eco House in Panama

We are very pleased to offer our beautiful, modern, comfortable house designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and escape daily stress. It is in a beautiful part of Panama near a cloud forest national park. The house sits in 17 acres of forest and has 2 rivers for swimming. The house is very open allowing full enjoyment of nature. There are amazing hiking opportunities in the mountains with waterfalls and visits to local communities.

Guest favorite

Cabin in Chicá

4.96 out of 5 average rating, 138 reviews

Cabaña Horizonte by Casa Amaya

Relax at this unique and peaceful getaway in Cabaña Horizonte. Casa Amaya is a complex of 6 cabins located in Chicá de Chame, cool climate between 18 and 24 degrees, where you can contact nature and relax with your partner, friends or family. https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/buenavistabycasaamaya https://www.airbnb.com/h/panoramabycasaamaya We have an electric generator in case of outage.

Guest favorite

Villa in Punta Chame

4.99 out of 5 average rating, 110 reviews

Beach House with Pool/Gazebo in Punta Chame!

"Disconnect from the routine and enjoy a sunny environment. Just breathe fresh air in a different surroundings. Enjoy a few days in the pool, relaxed in a hammock and of course steps from a spectacular beach with views of the city and islands. The house has 4 bedrooms, 3.5 bathrooms, electric plant and all the facilities to enjoy and rest. Close to restaurants and the best beach to do and see kitesurfing adventures, fish, SUP, etc. Only 90 minutes from the city"

Guest favorite

Home in Taboga Island

4.97 out of 5 average rating, 159 reviews

Casa Rosie - Dream Home on Tabogá Island

Casa Rosie is a gorgeous villa on Taboga island with an intimate vibe and spectacular views of the ocean. The perfect place for couples, small groups, and families to unwind and make magical memories! . With great wifi, fully equipped kitchen, 3 inviting bedrooms, and a spacious yet personal feel… Casa Rosie is your home away from home. Included in every stay is free pick up and drop off to the ferry terminal - please let us know the details of your arrival.

Superhost

Home in Vista Mar Golf, Beach & Marina

4.88 out of 5 average rating, 236 reviews

Luxurious Beach House - Private Pool Golf & Marina

Vista Mar Golf, Beach & Marina is a gated community with private security, with direct access to a state of the art golf course designed by J. Michael Poellot. It also has marina, heliport, tennis courts, direct private beach access, bars and restaurants. The house comes with an outdoor private pool & hot tub, also a amazing private outdoor kitchen, and an amazing sea view with spectacular sunrises and sunsets. any inquiry please contact 66168596

Guest favorite

Camper/RV in El Valle de Antón

4.98 out of 5 average rating, 188 reviews

Armadillo Shelter & Garden. Valle de Anton

Es un alojamiento unico y especial que hemos diseñado para que experimentes el Valle de Anton de una forma mas consciente y natural. Es un RV o remolque remodelado, para hacerlo acogedor>funcional y cómodo >estilo tiny house. El espacio tiene una pequeña y completa cocina, agua caliente, wifi, café y te. Se encuentra rodeado por un lindo jardín. Con entrada independiente y un area para estacionar el auto. Es ideal para 1 o 2 personas.

Guest favorite

Home in Las Colinas de Caceres de Arraijan

4.98 out of 5 average rating, 199 reviews

Tropical Haven with Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Guest favorite

Rental unit in Nueva Gorgona- Panamá Oeste

4.8 out of 5 average rating, 270 reviews

Lovely Beach Apart. seafront*Royal Palm*P.Gorgona

Private beach apartment, on high floor, with ocean view, two bedrooms, one bathroom, high quality appliances, remote lighting control on any mobile devices, A/C in bedrooms and living room. Netflix and Amazon Prime services on televisions. Tennis courts, basketball, soccer, gym, barbecue area and playground, two floors of social area, swimming pool for exercise and recreation for adults & children's pool) direct access to the beach.

Superhost

Condo in Panama

4.93 out of 5 average rating, 183 reviews

Beach apartment with pool and slides! 101

Cozy beachfront apartment fully furnished and equipped just 30 kilometers from Panama City. The apartment has the best residential location as it is steps from the beach club (swimming pool, slides, sand volleyball court, the beach, etc.). When staying with us we include complimentary access to the club where you can enjoy all its amenities. The club opens Tuesday through Sunday from 8am to 6pm, the slides close at 5pm.

Guest favorite

Rental unit in Veracruz

4.91 out of 5 average rating, 125 reviews

Studio on a beachfront property near Panama city

The village name is Veracruz, this is a small fishing village located at the pacific ocean. It´s 20 minutes driving to Panama city. There are public buses or taxis available 24/7 The studio is located in a very quit área of Veracruz. And it´s an ideal place to retrait in the evening and enjoy the tranquility. On the beach of Veracruz are several nice restaurants and bars with live music located

Guest favorite

Cottage in Altos del Maria

4.93 out of 5 average rating, 116 reviews

Mountain Cottage with Great View and Heated Pool

Casa de Montaña, with spectacular views of the mountains of Altos del María, perfect to rest or spend it with family, with heated pool, spacious outdoor spaces, Smart TV and A/A in all rooms, WIFI throughout the property and fully equipped. Includes Prime Video service. It has fire pit and a gas fired BBQ. For weekend rentals saliendo Domingo, se da da late check out complimentary.