Pet-friendly vacation rentals in Cape Girardeau County

Find and book unique pet-friendly homes on Airbnb

Top-rated pet-friendly home rentals in Cape Girardeau County

Guests agree: these pet-friendly homes are highly rated for location, cleanliness, and more.

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Guest favorite

Bungalow in Cape Girardeau

4.95 out of 5 average rating, 19 reviews

Large Home next to Southeast Hospital - 2 King Bed

Enjoy exploring Cape Girardeau with your group of friends or family by spreading out in our spacious 3-bedroom home! Just moments from downtown, this home is the perfect place to get ready for your night out on Broadway, or to relax as a group while using our open space living room & fully equipped kitchen. We have generous sleeping arrangements with large bedrooms, multiple King size beds, or cozy up on the couch to watch your favorite show or spend some quiet time relaxing in the den in fron

Guest favorite

Rental unit in Cape Girardeau

4.95 out of 5 average rating, 210 reviews

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

Superhost

Loft in Cape Girardeau

4.92 out of 5 average rating, 100 reviews

Riverwalk Loft 1

If you are looking for something right in the middle of the excitement, book now! This is your place. Our lofts are right in the heart of Downtown. In walking distance to breweries, casinos, and shopping galore.Our building is directly in front of the Mississippi River entrance. Walk around the corner either to get an ice cream for a late night snack. Beds are super comfortable but downtown isn’t the quiet part of town. The train runs periodically. You will have the typical night life noise.

Superhost

Home in Cape Girardeau

4.79 out of 5 average rating, 95 reviews

Herman’s Cozy Corner

This cozy home is conveniently located in the heart of historic Cape Girardeau. There is a nice and cozy back deck with a privacy fence to hang out and BBQ with your guests. There is plenty of off street parking available. All the essentials are here to keep your trip filled with convenience and comfort. Come enjoy the little extra privacy you’d get from booking this entire house for you and your guests. This home will make your trip to Cape Girardeau convenient, quiet, and affordable.

Guest favorite

Barn in Cape Girardeau

4.96 out of 5 average rating, 150 reviews

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint

Guest favorite

Guest suite in Cape Girardeau

4.86 out of 5 average rating, 70 reviews

[*Charming Cozy Suite*]

Forget your worries in this spacious, serene, and private Suite. The Suite has its own private entrance and is a converted walkout basement area. Located in one of the most peaceful and safest neighborhoods in Cape Girardeau, the Suite is a private and extra spacious 900 sq. foot studio. Complimentary WiFi, snacks, coffee, and more is designed to make you feel right at home. The Studio Suite is a within a 7-minute drive to all the local attractions Cape Girardeau offers.

Superhost

Home in Cape Girardeau

4.83 out of 5 average rating, 6 reviews

Cottage Near Casino

Welcome to your cozy cottage with a delightful retro feel, conveniently located near the Casino, Downtown, and SEMO University. You'll be greeted by the inviting sight of a white fence that surrounds the property, adding a touch of quaint charm to home away from home. This home features 2 bedrooms, 1 full bathroom and the convenience of main floor laundry. This is the perfect haven for traveling nurses or professionals seeking a comfortable and stylish residence.

Guest favorite

Rental unit in Cape Girardeau

4.89 out of 5 average rating, 94 reviews

Visit the "Gone Girl" neighborhood

Suite located in "Gone Girl" filming district. Living rm/bedrm, full kitchen, ADA bath, and walk in closet. Fully equipped with dishes,linens, refig, micro,stove, keurig, dishwasher and welcome home snacks. Double Murphy bed, queen hide a bed couch convert the living room to bedroom. Space is good for up to 3 adults, 2 adults and 2 children or a single guest. We accept well mannered dogs up to 50 pounds. See pets section for dog guest guidelines.

Guest favorite

Home in Cape Girardeau

4.85 out of 5 average rating, 116 reviews

Lucky King-4-bedroom Steps away from the casino

Directly across the street from Century Casino. This 4 Bedroom, 2 Bath home Sleeps 11 and is perfect for larger groups staying together. Completely remodeled with design touches that highlight all of Cape Girardeau's wonderful history. Three of the 4 bedrooms have king size beds. One bedroom offers one queen bed and one twin. In addition to 4 bedrooms, the living room features a pullout couch. Plenty of parking and in a very private location.

Rental unit in Cape Girardeau

5 out of 5 average rating, 3 reviews

brick and beam river escape

Stay in this unique 2-bedroom, 1.5-bath loft in downtown Cape Girardeau, housed in a historic building originally built in the mid-1800s by Irish immigrant Patrick Dempsey. Once the Dempsey Grocery Store and later a local bar, this space blends industrial charm with modern comforts. Enjoy open living areas, high ceilings, and exposed brick. Located steps from local restaurants, shops, and the Mississippi River

Guest favorite

Home in Cape Girardeau

4.93 out of 5 average rating, 14 reviews

Clean home great Neighborhood - central location

You must have at least 3 past 5 star reviews to rent this home. You must be 25 years of age. My home is located on a quiet cul-de-sac and I have wonderful quiet neighbors on each side of me. A inclined driveway will bring you to a two car garage as well as extra parking on the side of the home as well as the street. The Garage is not used for parking. Insurance purchase required to rent