Waterfront vacation rentals in Cape Girardeau County

Find and book unique waterfront rentals on Airbnb

Top-rated waterfront rentals in Cape Girardeau County

Guests agree: these waterfront rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Cape Girardeau

4.89 out of 5 average rating, 36 reviews

Ace Of Hearts- 1 Bed 1 Bath

Directly across the street from Century Casino, this 1 Bed- 1 Bath home sleeps 2. Perfect for a weekend away or an elevated stay when traveling for work. Completely remodeled, be one of the first to stay in this iconic home that was built in the 1930's to house factory workers from the historical red star shoe company. Stylish interior and an exterior view like no other, sip your coffee in style. Enjoy cooking in a full kitchen or take a walk downtown to enjoy beautiful shops and restaurants.

Private room in Cape Girardeau,

4.67 out of 5 average rating, 261 reviews

Super Comfy Mahogany Bed Quiet Safe

Cheerful, second-floor bedroom. Part of a two-bedroom guest suite. Comfy solid Mahogany bed and fabulous mattress, soft sterile sheets, fluffy pillows, vintage satin bed throw. Quiet, safe neighborhood. NON-party home. Great location 1.2 miles from SEMU, easy walk to groceries, 1 mile to riverfront restaurants like 36, Broussard's Cajun Cuisine, Century Casino, 2 miles to St Francis Medical Center. 1 mile to Mary Jane Smokehouse. One hour to freshwater springs, Castor shut-ins, hiking

Guest favorite

Loft in Cape Girardeau

5 out of 5 average rating, 17 reviews

Lorimier Loft Gallery next to SEMO River Campus

Directly across from Southeast Missouri State University’s River Campus, Lorimier Loft Gallery features luxury accommodations, purchasable gallery artwork and easy access to historic downtown Cape Girardeau. Every inch of this space delivers an aesthetic experience from the artwork to the tile-work to the location: Cross the street for performing art at the River Campus. Sit on the porch and listen to the marching band practice. Curl up by the fire and soak in a rich gallery during your stay.

Superhost

Loft in Cape Girardeau

4.92 out of 5 average rating, 100 reviews

Riverwalk Loft 1

If you are looking for something right in the middle of the excitement, book now! This is your place. Our lofts are right in the heart of Downtown. In walking distance to breweries, casinos, and shopping galore.Our building is directly in front of the Mississippi River entrance. Walk around the corner either to get an ice cream for a late night snack. Beds are super comfortable but downtown isn’t the quiet part of town. The train runs periodically. You will have the typical night life noise.

Guest favorite

Home in Cape Girardeau

4.97 out of 5 average rating, 126 reviews

River Run

Charming 1940s farmhouse. Updated 1 1/2 story house in a rural setting overlooking the Mighty Mississippi River, but close to the heart of Cape Girardeau. Our house has lots of room to relax with a large kitchen and sunroom. You can sit by a cozy fire pit and enjoy chilly evenings watching the beautiful sunsets. We look forward to you spending time in our neck of the woods (so to speak). We are located with in seven miles from the Isle casino, SEMO state university and a happening down town.

Guest favorite

Rental unit in Scott City

4.95 out of 5 average rating, 40 reviews

RiverSide Barn Suite on the Mississippi River.

The barn suite is a beautiful 2 bedroom apartment overlooking the Mississippi River and housed in a unique barn with its own separate entrance. The deck views are spectacular and takes sitting and relaxing to a new level. Our wine place “The RiverHouse “ is within walking distance with the best worldwide wines and menu in the area. www.theriverhousewineplace.com We are 12 minutes from Cape Girardeau and serviced by Lyft & Car-Go. You May contact us by text or call and available at any time.

Guest favorite

Treehouse in Cape Girardeau

4.99 out of 5 average rating, 101 reviews

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

Guest favorite

Rental unit in Old Appleton

5 out of 5 average rating, 22 reviews

Apple Creek Loft

Make some memories at this unique and family-friendly place. Enjoy what many remember to be the Old Store in Old Appleton. Have a peaceful experience near the Historic Bridge spanning the Apple Creek waterfall. Enjoy kayaking, fishing, and swimming in the creek right outside your door. This destination has beds to accommodate 6 people. Plus, there is a spacious living room and master bedroom where more guests could sleep if they would like to bring an air mattress/sleeping bag.

Guest favorite

Home in Cape Girardeau

4.78 out of 5 average rating, 40 reviews

Historical Home and River View

Escape to our riverside AirBnb in Cape Girardeau, MO! Enjoy stunning views of the Mighty Mississippi and the convenience of being near Southeast Missouri State University, a casino, and downtown attractions like Spectrum Record Lounge, Minglewood, Top of the Marq, and the Ground-a-Bout coffee shop. Relax in our cozy 3 bedroom, 2 bathroom home with a fully equipped kitchen, ample space, and the best view! Let us ensure your stay is unforgettable. Welcome to your home away from home!

Superhost

Rental unit in Cape Girardeau

4.75 out of 5 average rating, 20 reviews

The Outlook - Private Balcony

Welcome to 115 N Water, Unit 103 in Cape Girardeau, MO! This delightful property not only offers a cozy retreat but also boasts a private balcony with stunning, unobstructed views of the Mighty Mississippi River. Perfectly situated close to downtown, it's just steps away from a vibrant nightlife scene, with numerous bars and restaurants for an unforgettable date night experience. Enjoy the best of both worlds – scenic beauty and lively entertainment – right at your doorstep!

Superhost

Farm stay in Jackson

4.83 out of 5 average rating, 18 reviews

Beautifully Renovated Farmhouse in Jackson, MO

Originally built to be a homestead, it boasts a spring fed pond, creek, several species of nut trees and a history of all natural fruits, vegetables, pork, free-range chicken and grass-fed beef and lamb. A once private property owned by the Strack family, Rusted Route Farms opened to the public for the first time with Jones Heritage Farm and Market. Heritage Farms brought the community to feast with its delectable brunch and a wide variety of all natural goods.