Waterfront vacation rentals in Cape Girardeau County

Find and book unique waterfront rentals on Airbnb

Top-rated waterfront rentals in Cape Girardeau County

Guests agree: these waterfront rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Loft in Cape Girardeau

5 out of 5 average rating, 17 reviews

Lorimier Loft Gallery next to SEMO River Campus

Directly across from Southeast Missouri State University’s River Campus, Lorimier Loft Gallery features luxury accommodations, purchasable gallery artwork and easy access to historic downtown Cape Girardeau. Every inch of this space delivers an aesthetic experience from the artwork to the tile-work to the location: Cross the street for performing art at the River Campus. Sit on the porch and listen to the marching band practice. Curl up by the fire and soak in a rich gallery during your stay.

Superhost

Loft in Cape Girardeau

4.92 out of 5 average rating, 102 reviews

Riverwalk Loft 1

If you are looking for something right in the middle of the excitement, book now! This is your place. Our lofts are right in the heart of Downtown. In walking distance to breweries, casinos, and shopping galore.Our building is directly in front of the Mississippi River entrance. Walk around the corner either to get an ice cream for a late night snack. Beds are super comfortable but downtown isn’t the quiet part of town. The train runs periodically. You will have the typical night life noise.

Guest favorite

Home in Cape Girardeau

4.97 out of 5 average rating, 127 reviews

River Run

Charming 1940s farmhouse. Updated 1 1/2 story house in a rural setting overlooking the Mighty Mississippi River, but close to the heart of Cape Girardeau. Our house has lots of room to relax with a large kitchen and sunroom. You can sit by a cozy fire pit and enjoy chilly evenings watching the beautiful sunsets. We look forward to you spending time in our neck of the woods (so to speak). We are located with in seven miles from the Isle casino, SEMO state university and a happening down town.

Guest favorite

Rental unit in Scott City

4.95 out of 5 average rating, 40 reviews

RiverSide Barn Suite on the Mississippi River.

The barn suite is a beautiful 2 bedroom apartment overlooking the Mississippi River and housed in a unique barn with its own separate entrance. The deck views are spectacular and takes sitting and relaxing to a new level. Our wine place “The RiverHouse “ is within walking distance with the best worldwide wines and menu in the area. www.theriverhousewineplace.com We are 12 minutes from Cape Girardeau and serviced by Lyft & Car-Go. You May contact us by text or call and available at any time.

Guest favorite

Treehouse in Cape Girardeau

4.99 out of 5 average rating, 103 reviews

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

Guest favorite

Rental unit in Old Appleton

5 out of 5 average rating, 22 reviews

Apple Creek Loft

Make some memories at this unique and family-friendly place. Enjoy what many remember to be the Old Store in Old Appleton. Have a peaceful experience near the Historic Bridge spanning the Apple Creek waterfall. Enjoy kayaking, fishing, and swimming in the creek right outside your door. This destination has beds to accommodate 6 people. Plus, there is a spacious living room and master bedroom where more guests could sleep if they would like to bring an air mattress/sleeping bag.

Guest favorite

Home in Cape Girardeau

4.79 out of 5 average rating, 42 reviews

Historical Home and River View

Escape to our riverside AirBnb in Cape Girardeau, MO! Enjoy stunning views of the Mighty Mississippi and the convenience of being near Southeast Missouri State University, a casino, and downtown attractions like Spectrum Record Lounge, Minglewood, Top of the Marq, and the Ground-a-Bout coffee shop. Relax in our cozy 3 bedroom, 2 bathroom home with a fully equipped kitchen, ample space, and the best view! Let us ensure your stay is unforgettable. Welcome to your home away from home!

Private room in Cape Girardeau,

4.67 out of 5 average rating, 261 reviews

Comfy Mahogany room Close to Mercy Hospital

Cheerful, second-floor bedroom. Part of a two-bedroom guest suite. Comfy solid Mahogany bed and fabulous mattress, soft sterile sheets, fluffy pillows, vintage satin bed throw. Quiet, safe neighborhood. NON-party home. NO SMOKING .. not 430 friendly . Great location 1.2 miles from SEMU, easy walk to groceries, 1 mile to riverfront restaurants like 36, Broussard's Cajun Cuisine, Century Casino, 2 miles to St Francis Medical Center. 5 minuets to mercy hospital

Superhost

Farm stay in Jackson

4.84 out of 5 average rating, 19 reviews

Beautifully Renovated Farmhouse in Jackson, MO

Originally built to be a homestead, it boasts a spring fed pond, creek, several species of nut trees and a history of all natural fruits, vegetables, pork, free-range chicken and grass-fed beef and lamb. A once private property owned by the Strack family, Rusted Route Farms opened to the public for the first time with Jones Heritage Farm and Market. Heritage Farms brought the community to feast with its delectable brunch and a wide variety of all natural goods.

Guest favorite

Loft in Cape Girardeau

4.9 out of 5 average rating, 195 reviews

Riverwalk Loft 3

Historical building with modern amenities. We are located right in the middle of downtown life. With the excitement there will come noise from bars, live bands, and the occasional train. If you love staying where fun is happening, this ones for you. Please note: we are located above an arcade bar and you are a building up from the River wall. There is also a currently operational TRAIN track with TRAINS, that make TRAIN noises 200ft from our lofts.

Guest favorite

Rental unit in Cape Girardeau

5 out of 5 average rating, 5 reviews

brick and beam river escape

Stay in this unique 2-bedroom, 1.5-bath loft in downtown Cape Girardeau, housed in a historic building originally built in the mid-1800s by Irish immigrant Patrick Dempsey. Once the Dempsey Grocery Store and later a local bar, this space blends industrial charm with modern comforts. Enjoy open living areas, high ceilings, and exposed brick. Located steps from local restaurants, shops, and the Mississippi River