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House vacation rentals in Mesa County

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Top-rated house rentals in Mesa County

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Home in Grand Junction

4.85 out of 5 average rating, 712 reviews

Happy Hippie House

Welcome to our beautiful, 1950 home known by our guests as the Happy Hippie House! Our home's interior has been updated, giving it a fresh, chic hippie vibe. The eclectic decor creates a light & airy interior. Come hang out on the front porch! Discover wineries, skiing, hiking, biking, kayaking & rafting. Minutes from CMU, hospitals, & a lovely downtown area. Free Wi-Fi & Roku w/Netflix. Electronic lock for easy late check-in. LGBT & 420 friendly (outside)! Earns 5 stars for convenient location.

Home in Orchard City

4.95 out of 5 average rating, 460 reviews

The Orchard House

**A devastating freeze in October 2020 killed all 400 of our sweet cherry trees and many of our peach trees. Sadly, our orchard is not the lush green jewel it once was. We are planting new cherry trees in the Spring of 2022. While the orchard views have changed, the Orchard House continues to offer a very comfortable place to rest and recharge. Come enjoy fresh air and quiet whether you are stopping through on a road trip or staying longer for local adventure. Fast WiFi for telecommuting!

Home in Paonia

4.92 out of 5 average rating, 676 reviews

Kale's Private & Romantic Cottage - King, Kitchen

Kale's Cottage features a kind size bed and is the epitome of unique and comfortable stays in Western Colorado. Our award-winning, pet-friendly Solargon boasts an elegant design, and is located just a half-mile walk away from the charming downtown of Paonia. The 374 sq ft space offers a fully stocked kitchen, seasonal wood stove, work/dining table & spacious private bathroom with shower. Whether for a special getaway, work, hiking, business or adventure, this is your perfect home away from home.

Home in Fruita

4.95 out of 5 average rating, 258 reviews

The Wandering Nomad

Bring your heavy laden feet to rest in a wanderlust inspired home that will bring even the tamest nomad in you to surface. This 3 bed, 2 bath space is complete with everything needed for the modern day wayfarer. Spend the day on world-famous trails only to return to this suburban retreat, walking distance from the local fun and fare. Wifi is found throughout the home so you can stay connected to the world around you...or not. Life is all about choices and we hope you choose us as your home away.

Home in Grand Junction

4.97 out of 5 average rating, 159 reviews

Resort-like Adobe At Colorado Monument!

This newly renovated adobe style home will make you feel like you’re in a resort with amazing views. Perfect for a family vacation, girls/guys trip, mountain biking trip, romantic getaway, wine tasting or just a weekend getaway this is the perfect home. Close to many outdoor activities including hiking, fishing, mountain biking, Paddle boarding/kayaking/tubing, golfing. Located 5 mins to Two Rivers and 25 mins to Palisade vineyards. We are offering the complete Colorado outdoor experience.

Home in Loma

4.93 out of 5 average rating, 221 reviews

The Barn

THE BARN. This is a guest house on 10 acres surrounded by farmland. It has 3 bedrooms, 2 full bathrooms, a sofa bed, full kitchen and dining, full laundry set up and 2 car garage. We call it the barn because it looks like a barn and is frequently mistaken as a barn. A real wood fireplace in living room makes this a cozy place to stay. Large patio offers unrestricted views. Located just a few miles from town so you are close to the main attractions and trails. RV/trailer parking available.

Home in Grand Junction

4.92 out of 5 average rating, 237 reviews

Colorful 2 bedroom pet friendly home

Make some memories at this unique and family-friendly place. Our home welcomes you and your pet/s to enjoy our 2 newly decorated bedrooms with blackout curtains, remodeled luxurious bathroom with 2 showerheads, full kitchen , laundry, pet door, dog run, back porch to sit and relax, and lovely backyard to enjoy. We encourage you to walk downtown, only 6 blocks away. The Colorado National Monument, regional airport, CMU, library, Science Center for kids, and bike trails are very close.

Home in Loma

5 out of 5 average rating, 494 reviews

Fruita/Loma Guest House at the Perfect Day Getaway

This newly constructed "Green" home is a mix of modern and country styles and will surely inspire you to enjoy all of the outdoor activities the Grand Valley has to offer. The Perfect Day Getaway house is located on a quaint farm within 8 minutes of world-class hiking, mountain and road bicycling, and river rafting. It is a great launching point for day trips to Moab and the Grand Mesa as well! It was built to maximize the southern exposure and views of the Colorado National Monument.

Home in Palisade

4.96 out of 5 average rating, 248 reviews

Galloway Ranch Palisade Colorado

Recent review: The best place we've ever stayed at, hands down! The location felt like a dead end road, yet close to everything. The yard had beautiful flower beds, not to mention the amazing view of Mt. Garfield! The house itself was very comfortable and had anything you can imagine in the kitchen, making a few at home dinners a breeze. Owners Note: One (1) dog 45 lbs max allowed unless an additional dog is approved in advance, please include # of people and # of dogs when booking.

Home in Palisade

4.9 out of 5 average rating, 153 reviews

The Pali House B - Beautiful Home on 10 acres

Thank you for considering a stay at our newly remodeled home, designed with luxury and comfort in mind. Enjoy the privacy of being on 10 acres with incredible views while still being 3 minutes to wineries and 7 minutes to downtown Palisade. House B is the downstairs unit of this two story ranch home. With a private, walkout basement entrance, living room, dining room, and fully stocked kitchen. The large yard is recently landscaped and perfect for dogs! Your hosts, Joe & Trish

Home in Grand Junction

4.86 out of 5 average rating, 229 reviews

Blue House - Dog, RV, and Trailer Friendly

The Blue House is located just south of downtown Grand Junction, adjacent to the Mesa County Fairgrounds and the Old Spanish Trail BLM area. It is also within bicycling distance of Downtown, Los Colonias, Riverfront Trail and Lunch Loop Trails. The house is a corner lot on a quiet dead-end street. Extensive outdoor spaces are the highlight here - perfect for dogs, aggressive children, and off-leash adults. RV/trailer parking with 30 amp service is also available.

Home in Grand Junction

4.98 out of 5 average rating, 118 reviews

Downtown! 2 blocks to Main Street! Art on White!

✨Art on White gives you an artistic, vintage, downtown experience with access to world-class mountain biking, wine tasting, vineyards and so much more! Our vintage home built in 1905, has quite a unique experience to offer. With love for our Community and Art in mind, we feature local artists and sculptors work throughout the home. This eclectic space provides a relaxing, whimsical, light & airy stay. We love this house and we hope you do too!! 😊

Vacation rentals for every style

Get the amount of space that is right for you

Cabins

Kick off your hiking boots at these rustic lodgings

Apartments

Convenient locations with everyday essentials

Cottages

Quaint homes, peaceful surroundings

Popular amenities for Mesa County house rentals

Free parking on premises

Air conditioning

House rentals with a pool

Home in Grand Junction

New place to stay

*New:Pool~HotTub~TikiBar~GameRoom~FirePit~MiniGolf

Home in Grand Junction

5 out of 5 average rating, 68 reviews

Pool, hot tub, views and close to everything

Home in Palisade

4.92 out of 5 average rating, 191 reviews

Peach Pad! hot or cool tub 2 bedrooms 2 bathrooms

Home in Grand Junction

4.29 out of 5 average rating, 7 reviews

The Whole Package Kind of Place!

Home in Palisade

4.81 out of 5 average rating, 59 reviews

Palisade Peach Orchard Farmhouse w/Pool & Spa 18+

Home in Clifton

4.91 out of 5 average rating, 75 reviews

The Honey Bee @ Palisade Legends

Weekly house rentals

Home in Hotchkiss

4.95 out of 5 average rating, 164 reviews

The Moon House. Come mingle with the stars.

Home in Delta

4.99 out of 5 average rating, 142 reviews

Fully Stocked 3 BR HOME - Work & Play w/fast WiFi

Home in Palisade

5 out of 5 average rating, 79 reviews

Love Orchard

Home in Fruita

4.98 out of 5 average rating, 182 reviews

The Centennial House ~ Your Adventure Starts Here!

Home in Grand Junction

4.92 out of 5 average rating, 173 reviews

5200SqFt, Hillside Rock In House, Stunning Views

Home in Grand Junction

4.93 out of 5 average rating, 238 reviews

Monument Paradise on golf course

Home in Grand Junction

4.85 out of 5 average rating, 175 reviews

Monumental Memories

Home in Delta

4.83 out of 5 average rating, 24 reviews

Cottage

Private house rentals

Home in Palisade

4.98 out of 5 average rating, 98 reviews

Peach Chalet, views, quiet, 5 min to downtown

Home in Mesa

4.9 out of 5 average rating, 89 reviews

Powderhorn Grand Mesa Classy Family Cabin

Home in Grand Junction

4.84 out of 5 average rating, 45 reviews

Luxury Home/ Hot Tub

Home in Delta

5 out of 5 average rating, 18 reviews

Escalante Escape- It's home!

Home in Grand Junction

4.83 out of 5 average rating, 66 reviews

Serene Riverwalk Retreat

Home in Grand Junction

4.96 out of 5 average rating, 73 reviews

Beautiful, Cozy, Private, Clean~ 3 Bedroom Home

Home in Fruita

4.96 out of 5 average rating, 45 reviews

The Peach House

Home in Cedaredge

4.9 out of 5 average rating, 20 reviews

Log Beam Lodge

Destinations to explore