Guesthouse vacation rentals in Mississippi River

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Top-rated guesthouse rentals in Mississippi River

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Sarcoxie

5 out of 5 average rating, 104 reviews

Quiet Acres Hidenaway Off I-44

Take it Easy at this Unique and Tranquil Getaway Where the Silence is Very Peaceful and Calming! Only 2 and Half Miles From/Off Interstate 44. ENJOY this Clean and Cozy Country Getaway Where You'll Wake up to Jersey Heifers Right Outside Each Window! Everything You'd Need for a Restful Night! Remember that Nature is our Backyard and Outdoor Sounds may happen. Also when living in the Country it is Very Common to Possibly see a Ladybug 🐞 or Cricket! NO PARTIES ABSOLUTELY NO HUNTING NO SMOKE

Guest favorite

Guesthouse in Sayner

4.98 out of 5 average rating, 177 reviews

Sauna & Peace, Pinely-Lands End at the Edge Loft

QUIET PRIVATE zenny retreat with large screened-in deck overlooks NHAL wilderness. Ponder a pine skyline & a plethora of stars! Howling wolves, a floodlight so you can watch it snow at night. Gas grill, firetable. Rustic SAUNA. WIFI, elect FP, kitch, 2 PAIR SNOWSHOES & a trail out the door. LostCanoe Lake, WhiteSand Lake BoatLaunch&Beach, Escanaba & Lumberjack St Trails in 5min. HeartofVilas paved Trl, Fallison Lake St Trl 20min. RusticRd #60 on the way. Semi-secluded yet 8mi to BJ restaurants!

Guest favorite

Guesthouse in Joplin

4.99 out of 5 average rating, 127 reviews

Mike & Angie’s Private-Cozy furnished Guest House

Are you needing a private and cozy, furnished Getaway or Work area? Welcome to Red Roof Creekside Getaway. We are Mike and Angie residence of Joplin. Small business owners supporting our community. Our wish is that everyone who stays with us will have a comfortable, relaxing, stress-free time. We're available for any questions or needs. Our guest house sits on a secluded, private, peaceful two-acre lot, surrounded by trees, a creek and lots of wildlife. Close by Route 66 and local amenities.

Guest favorite

Guesthouse in Omaha

4.9 out of 5 average rating, 117 reviews

Beautiful Secluded Cottage @Lacey Michele's Castle

Nestled in the beautiful Ozarks, Lacey Michele's Castle offers guests an exclusive, quiet getaway. Tucked away off Hwy 65, the castle is conveniently located about 15 minutes from Branson, 45 minutes from Buffalo River National Park and 1 hour from Eureka Springs & Bull Shoals. There are a number of attractions close to us, including Big Cedar Lodge, the Branson Landing, & Dogwood Canyon Nature Park. Lake access at Cricket Creek Marina only 10 mi away, where you can rent a boat for the day.

Guest favorite

Guesthouse in Berwick

4.98 out of 5 average rating, 219 reviews

Private Guest Lake House On 37 Acres In Country

Private guest lake house, located next to main house, on private lake in the country. 2 bedroom, 1 full bath, full kitchen, washer and dryer and large attached screen porch. Private 37 acres of woods and prairie. Fishing and walking trails. Great window views of lake, woods, prairies and river valley. Please note, this guest house is located 1 mile down a county maintained gravel road. 25 minutes from Galesburg, IL, 20 minutes from Monmouth, IL and 35 minutes from Macomb, IL.

Guest favorite

Guesthouse in Eudora

4.86 out of 5 average rating, 147 reviews

Cozy cottage getaway in garden paradise

Get away and relax in a whimsical octagonal cottage surrounded by a lush garden, overlooking a swimming pond and the Wakarusa river. You will have everything you need for a romantic date night or an inspiring place to slow down and reconnect with nature. •1 bedroom open living space with lots of natural light and beautiful views. • Coffee cart with microwave and electric burner and mini frig are provided. •Bikes and paddle boat are available to explore the property. •NO PETS ALLOWED

Guest favorite

Guesthouse in Blue Eye

4.98 out of 5 average rating, 120 reviews

Turtle Cove- Hot tub, Kayaks, Fire Wood Included

Come and enjoy a peaceful getaway in our quiet cove on Table Rock Lake. Relax in the guest house with a private deck, hot tub, outdoor shower, fire pit and beach at your back door! Enjoy swimming or fishing in the cove, sunning on a paddle board or kayaking at sunset. Paddle boards and kayaks included! Welcome family time relaxing on the hammock listening to the water lapping, barbecuing on the deck or chilling by the fire pit (firewood included). Come rejuvenate in nature's beauty!!

Guest favorite

Guesthouse in Lone Jack

4.93 out of 5 average rating, 258 reviews

Adorable cottage on Beautiful property w/ hot tub

Take it easy at this unique and tranquil getaway. Enjoy your own private cottage with all your essentials; vanity , bath with shower attachment, personal mini fridge and freezer, Smart TV equipped with Netflix and Hulu logged in. You also have access to the property's hot tub and 1 acre pond stocked with catfish, blue gill, and bass! I cottage has a 1 queen size bed and a mattress in the loft . Please note: we do live on this property and the cottage is next to our main house.

Guest favorite

Guesthouse in Rogers

4.98 out of 5 average rating, 139 reviews

The Penthouse in DTR

Enjoy a stay at the only Luxury apartment rental conveniently located just two blocks from downtown Rogers. The Penthouse in Downtown Rogers is a modern and stylish apartment with all the amenities you need for a short stay or a long retreat: sumptious Sleep Number bed and bedding, gourmet kitchen and outdoor barbecue area, luxe shower and outdoor hot tub with an outdoor fire pit to boot. Just 3 blocks from the Railyard mountain bike park, a short trail to lake Atalanta park.

Guest favorite

Guesthouse in Hamilton

4.98 out of 5 average rating, 182 reviews

Spacious 1 BR Carriage House - 2 min walk to MSQC

The Carriage House apartment is located behind the historic home we've restored in Hamilton. The property is nestled one block between popular Main Street shopping (featuring the Missouri Star Quilt Co. shops) and the Missouri Quilt Museum. Everything is within easy walking distance from this beautiful, newly built apartment. Plus, you'll enjoy plenty of space, a full kitchen, free wi-fi and free laundry on site. We can't wait to welcome you to your home away from home!

Guest favorite

Guesthouse in Rocheport

4.97 out of 5 average rating, 144 reviews

Just off the beaten path

Take it easy at this unique and tranquil getaway. 5 minutes from I-70. Enjoy nature in the woods in our cozy, quiet guesthouse. Close to the Katy Trail for cyclists, wineries, and I-70 for the weary traveler needing a quiet rest before hitting the city. We offer an easy, accessible place to store your bikes and gear. Coffee/tea to wake up enjoying breathtaking views from your private deck.

Guest favorite

Guesthouse in Republic

4.98 out of 5 average rating, 526 reviews

The Winsome Loft - NEW Arcade & Home Theater

The Winsome Loft is a dedicated second-story guest house providing all the comforts of home but the elegance of your favorite hotel. In addition, the loft is only about a 15–25-minute drive to Cox Hospital, Bass Pro, Wonders of Wildlife and more! Fun spaces include a full feature home theater, arcade, and basketball court. POOL Season starts end of May to mid September 2025.