House vacation rentals in Panama City

Find and book unique houses on Airbnb

Top-rated house rentals in Panama City

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Panamá

4.94 out of 5 average rating, 51 reviews

Cozy cabin in the mountains of Cerro Azul

Disfrute de la naturaleza y un clima agradable, alejado del ruido y el calor de la ciudad en esta espaciosa y hermosa cabaña, decorada con detalles de madera que dan una sensación de calidez increíble. En ella encontrará WIFI, TV y Netflix incluido. A solo 50 minutos de la ciudad, es el lugar perfecto para viajar con familia y amigos. Además para familias viajando con niños pequeños, le ofrecemos play y silla de comer. Escríbanos para cualquier duda y estaremos siempre disponible para ayudarle.

Superhost

Home in Panama City

4.69 out of 5 average rating, 16 reviews

Casa AcoModo @Casco Viejo (4Bdr Historic Mansion)

Discover the allure of Casco Viejo in our 4-bedroom Casa AcoModo, available for exclusive booking for the entire house or by apartments in the top or bottom floor. Each space blends historic charm with modern comfort, offering an intimate retreat in the heart of the historic city. Whether exploring nearby landmarks or relaxing on the private balcony, this residence captures the essence of Casco Viejo. Ideal for families, friends, or solo travelers seeking a unique and enchanting escape.

Superhost

Home in Punta Pacifica

4.76 out of 5 average rating, 70 reviews

Large Private Residence in Excellent Area

House in the best areas of the country. Very quiet street, downtown, near restaurants, pharmacies, malls among others. Large comfortable residence for groups or families. Private parking for up to 2 cars 4 Spacious bedrooms, 2 comfortable studios, living room, breakfast room, large terrace. *Opcion Kosher Disponible* House in one of the best area of the country. Very quiet street, central, close to restaurants, pharmacies, mall and more. Large comfortable residence for groups.

Guest favorite

Home in Panamá

4.91 out of 5 average rating, 22 reviews

Amazing mountain house

Disfruta de una escapada familiar en nuestra casa de montaña en Los Altos de Cerro Azul, donde la tranquilidad y la naturaleza te esperan. Con 3 hab, amplias terrazas para relajarte, una zona de BBQ ideal para parrilladas, y una acogedora zona de fogata para noches bajo las estrellas, es el lugar perfecto para desconectar. Casa, rodeada de impresionantes vistas y aire puro, aquí encontrarás el espacio ideal para crear recuerdos inolvidables. ¡Ven a disfrutar de la paz que mereces!

Guest favorite

Home in Panama City

4.9 out of 5 average rating, 40 reviews

Central, comfortable, surrounded by nature|parking

Conectar con la ciudad y la maravillosa naturaleza al mismo tiempo, te encantará. Descansar en una hamaca en el balcón y disfrutar de tu casa en la ciudad; lo hace único. Te quedará genial si deseas visitarnos de placer, trabajo; en familia o en grupos de amigos y tu mascota es bienvenida. Una casa de la Antigua Zona del Canal, Primer Alto; desde aquí para explorar lugares turísticos y restaurantes. Cercano a Albrook Mall, parque Metropolitano, Casco Antiguo, Coast Way de Amador.

Superhost

Home in Panamá

4.73 out of 5 average rating, 41 reviews

Private Pool House with BBQ and more

Enjoy a private pool, in the tranquil area of Albrook; historically, the Panama Canal Zone. 4 bedrooms, 4 bathrooms in this 3-story building designed for your comfort, and relaxation. With a bbq grill for those hot pool days, and a fully equipped kitchen for the cooking masters (or private chef service), this house is the perfect escape for vacations. Housekeeping included, with our professionally trained helper to ensure your safety and relaxation thorough.

Guest favorite

Home in Panamá

4.93 out of 5 average rating, 14 reviews

Cantabria House - 10 minutes from the Airport

Welcome to your home in Panama, near the Tocumen International Airport. This comfortable house is conveniently located 200m from the metro station, making it easy to access places of interest in the city. 500mbps wifi connection. The rooms are equipped with Air Condition for your comfort. The kitchen is fully equipped and for your entertainment, enjoy a wide selection of cable television channels. Book now and enjoy an unforgettable stay in Panama!

Guest favorite

Home in Panamá

5 out of 5 average rating, 10 reviews

Spacious Casa Familiar Aeropuerto

Just 6 minutes from Tocumen International Airport, our comfortable house is an excellent option to rest and relax, a safe and quiet place, you have a 24-hour Supermarket with Restaurant and Pharmacy, 3 minutes from Tocumen Hospital and Metro Station, 10 minutes from Centro Comercial Los Pueblos and Metromall. In our House you can enjoy 3 bedrooms, 2 bathrooms, A/C, large terrace, private parking, equipped kitchen, Wi-Fi and Netflix.

Guest favorite

Home in Panamá

4.89 out of 5 average rating, 18 reviews

Naturaleza marriosa

Enjoy a family retreat surrounded by nature, where tranquility surrounds you. This cozy home, surrounded by a beautiful garden in the Metropolitan Natural Park, offers you a unique escape just 3 minutes from the Albrook Mall and 5 minutes from downtown. Wake up to the song of the birds and the visit of ñeques, while relaxing in an exclusive and lively atmosphere. The perfect getaway to unwind and enjoy nature with all the amenities!

Guest favorite

Home in Panamá

4.93 out of 5 average rating, 14 reviews

Cozy Cabin in Los Altos de Cerro Azul

Relax with all family and friends in this quiet place and very cool weather to stay. Connect all your senses with nature. Panama ⛰️ City Highlands🇵🇦. Enjoy all the greenery around with its viewpoints, waterfall, lake, spas and rivers, not to mention the beautiful hiking trails. In the cabin you can rest, see the pines around, relax in the hammock area, enjoy the sun in cool weather or just sit on the terrace or deck.

Guest favorite

Home in Panamá

4.94 out of 5 average rating, 33 reviews

Unique 4 room house - direct access to the beach

Incredible newly renovated villa with the best location and views of the entire Old Town. There is no villa that is better located, with the sea at your feet and being able to enjoy the beach. Enjoy the best property in all of Casco Viejo, on the golden mile, on the beachfront. You will enjoy the best sunrises and sunsets, turning the sky completely pink and seeing the Panama Canal.

Guest favorite

Home in Panamá

4.93 out of 5 average rating, 322 reviews

Private Studio 10 Min from the airport !

Entero Apartment 10 MINUTES FROM the Airport! We make sure to create this space with all the comforts to ensure a peaceful stay. The apartment is fully furnished including appliances and kitchen items, toiletries , dining room, work table and so on. Just minutes walk from SAN ANTONIO METRO Station, restaurants, shopping malls,laundries,supermarkets and pharmacies.