House vacation rentals in Pickens County

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Top-rated house rentals in Pickens County

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Seneca

4.99 out of 5 average rating, 185 reviews

Lakeside @ Lake Hartwell in Clemson, SC 🐟🌅🚤

Lake lovers and college football fans...you will LOVE this house! Lots of privacy, huge kitchen, dock, fire pit, gas grill, kayaks, and more! Beautiful Lake Hartwell home… where 1000 miles of shore awaits you! Our home is located just minutes away from Clemson, Seneca, Anderson, and more! Just 25 steps to your private dock, and 7 miles/ 10 mins from Death Valley (Memorial Stadium!) 4 bedrooms, and 3 full bathrooms. You must be at least 25 to rent. NO pets allowed, sorry! No fireworks.

Guest favorite

Home in Seneca

4.95 out of 5 average rating, 161 reviews

Private lake setting close to Clemson University

House is located in a private community yet only 2.5 miles to Death Valley and Clemson. Enjoy a walk down to the lake or relax on the back deck. WIFI is included with access to Hulu and Disney+. Kid friendly as well. Property is also within 1.2 miles of Oconee Airport, 0.7 miles to a dock, 1.5 miles to the grocery store, and less than 1.3 miles to Y beach public parking (avoid game day traffic if you are coming in for football). Close to everything in Oconee, Pickens and Anderson Counties.

Guest favorite

Home in Pickens

4.96 out of 5 average rating, 167 reviews

“Mountain View Paradise” Waterfall Oasis

STORM UPDATE: NO INTERNET. The peaceful sounds of a Rushing Waterfall welcome you to “Mountain Paradise”. Surrounded by 500 acres of forest and waterfalls, you have the ultimate level of privacy. Exquisitely furnished oasis with 3 bedrooms and 3 Full Baths. Enjoy 2 Master Suites with their own en suite Master Baths. Enjoy a game of golf at The Rock Golf Resort. Lake Keowee and Lake Jocassee are just minutes away. Visit Greenville, SC or head up to Brevard, NC both just 45 minutes away.

Guest favorite

Home in Pendleton

4.89 out of 5 average rating, 150 reviews

Comfort & Convenience Close to Campus

The perfect blend of modern charm and full comfort & convenience just minutes from Clemson, The Pendleton Square and HWY access. You will be sure to have everything you need for your visit. Comfortably sized bedrooms with queen size beds. Spacious living area with cable TV & Netflix. Bright and open kitchen and dining fully equipped for all your cooking needs. Whether you're traveling alone for a little peace & quiet, with friends, or with family... we hope you enjoy your time here!

Guest favorite

Home in Salem

4.99 out of 5 average rating, 118 reviews

Keowee Key Luxury Condo - Stunning Views!

Freshly renovated condo at the sought after Tall Ship condos in Keowee Key. This is hands down the best unit the complex has to offer with amazing views. Enjoy grilling out on the patio overlooking the marina, walking on the trail, or relax in the pool which is only a short walk away. This is truly a paradise. Guest boat slip is available at the marina for boats or jet skis. Slip is $50 per day. Recommended to book one month in advance.

Guest favorite

Home in Pickens

4.97 out of 5 average rating, 146 reviews

Our Slice of Heaven w/Views of Table Rock-Pickens

Our slice of heaven is located in the foothills of the Blue Ridge Mountains only 8 mins from Table Rock State Park. Our guest house is sitting on 55 wooded acres with our 4-acre pond and amazing awe-inspiring panoramic views of Pinnacle and Table Rock Mountain. Wrap yourself in the serenity of nature, with nothing more to wake you in the morning than the pleasant sounds of songbirds beckoning you to delight in the new day.

Guest favorite

Home in Pickens

4.97 out of 5 average rating, 150 reviews

Hidden Retreat

7 private acres just off Hwy 11. HIKE - connector to the Palmetto trail and Table Rock State Park. BIKE - popular biking routes; Hwy 11, Hwy 288 and Hwy 178 + Doodle & Swamp Rabbit Trail. GOLF - 1 course 5 minutes away several others nearby. WATERFALLS - including the highest in the east. MOUNTAIN LAKES - 2 of the best, Jocassee & Keowee. HIDDEN RETREAT - close to many outdoor adventures. Up to 6 guests.

Guest favorite

Home in Easley

4.89 out of 5 average rating, 110 reviews

Livin' Easley-walk to downtown-close to everything

Welcome to Livin' Easley! Your family will be close to everything when you stay at this newly renovated bungalow style house. Downtown Easley shops, restaurants, bars and The Silos are within walking distance, and Greenville and Clemson are just a short drive away. If you'd rather stay in, enjoy everything the house has to offer including bumper pool, a card table, board games, horseshoe pits, and Netflix.

Guest favorite

Home in Seneca

4.99 out of 5 average rating, 195 reviews

The Cozy Cottage

Beautiful, well-maintained home located in a private subdivision just minutes away from shopping, restaurants, lakes, golf courses, and Clemson University. This home has a fully equipped kitchen for dining in and a back patio for grilling out. Perfect for getaways, football weekends, graduation, and other Clemson University events! *NO SMOKING OR VAPING ALLOWED INSIDE THE HOUSE OR ON THE PROPERTY

Guest favorite

Home in Central

4.96 out of 5 average rating, 248 reviews

The Little House @ Cozy Hollow

Country living close to town. 2 miles from Cateechee Beach Park, 4 miles from SWU, 10 miles from Clemson, 12 miles from Oconee Nuclear Station, 13 miles from Garrison Arena, and 25 miles from Greenville. Enjoy your getaway at this private guest house with private drive, front & back porches, tv (streaming via Hulu Live, Disney+, Netflix, and more), washer/dryer, and full kichen including Keurig.

Guest favorite

Home in Easley

4.96 out of 5 average rating, 333 reviews

Blue Ridge Retreat

Escape to the Blue Ridge Retreat in the foothills of the Blue Ridge Mountains. Our pet-friendly entire home features a large fenced yard and is conveniently located near Clemson University, Greenville, and downtown Easley. Enjoy comfortable accommodations and all the amenities you need to feel at home. Book your stay now and experience the beauty of the upstate!