Guesthouse vacation rentals in South Carolina
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Top-rated guesthouse rentals in South Carolina
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for South Carolina guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Camden
4.94 out of 5 average rating, 192 reviewsRed Roof Loft @ FireFly Farm
Guesthouse in Summerville
4.87 out of 5 average rating, 770 reviewsNew Loft in Historic Summerville
Guesthouse in Beaufort
4.98 out of 5 average rating, 391 reviewsThe Wren Guest House
Guesthouse in North Charleston
4.93 out of 5 average rating, 378 reviewsCozy Park Circle, Charleston Guest House
Guesthouse in Columbia
5 out of 5 average rating, 400 reviewsCozy studio apartment, convenient location
Guesthouse in Donalds
4.99 out of 5 average rating, 359 reviewsHome on the farm
Guesthouse in Townville
4.86 out of 5 average rating, 247 reviewsLisa’s Lodge
Guesthouse in Pendleton
4.89 out of 5 average rating, 251 reviewsLa Bella Farm
Guest house rentals with a patio
Guesthouse in Hilton Head Island
4.9 out of 5 average rating, 135 reviewsAlli B's air B and B-great country access off 278
Guesthouse in Greenville
4.95 out of 5 average rating, 143 reviewsCozy Downtown GVL Studio
Guesthouse in Greenville
4.98 out of 5 average rating, 111 reviewsFinished Room over Garage (FROG) on Reedy River
Guesthouse in Charleston
4.99 out of 5 average rating, 120 reviewsThe James: “Tiny” Home b/w Downtown & Folly
Guesthouse in Johns Island
4.89 out of 5 average rating, 148 reviewsCozy Cottage! 5 mins from Kiawah!
Guesthouse in Abbeville
4.96 out of 5 average rating, 135 reviews1-bedroom guesthouse in Abbeville, SC
Guesthouse in Fort Mill
4.95 out of 5 average rating, 173 reviewsCarriage House Suite on Lake Wylie
Guesthouse in Charleston
4.98 out of 5 average rating, 113 reviewsLuxury Loft (2 miles from Folly Beach)
Guest house rentals with a washer and dryer
Guesthouse in Columbia
5 out of 5 average rating, 101 reviewsAmazing Studio Guesthouse in COLA suburb.
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 140 reviewsBeach, downtown, Alhambra Hall weddings so close!
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 239 reviewsCozy Apartment in Mount Pleasant
Guesthouse in Charleston
4.9 out of 5 average rating, 589 reviewsCute, Cozy, Charleston Cottage
Guesthouse in Six Mile
4.9 out of 5 average rating, 111 reviewsCamper at Hickory Lodge and Guesthouse
Guesthouse in Summerville
4.96 out of 5 average rating, 243 reviewsSummerville’s Tiny Oak Hideaway
Guesthouse in Lyman
4.99 out of 5 average rating, 145 reviewsBlue Heron Hideaway Lakeside Retreat
Guesthouse in Columbia
4.92 out of 5 average rating, 126 reviewsBrand New Studio Guest House with Full Kitchen.
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