Guesthouse vacation rentals in South Carolina
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Top-rated guesthouse rentals in South Carolina
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
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Popular amenities for South Carolina guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Charleston
4.91 out of 5 average rating, 676 reviewsIsland Oasis—Near Downtown
Guesthouse in Camden
4.94 out of 5 average rating, 191 reviewsRed Roof Loft @ FireFly Farm
Guesthouse in Summerville
4.87 out of 5 average rating, 769 reviewsNew Loft in Historic Summerville
Guesthouse in Beaufort
4.98 out of 5 average rating, 389 reviewsThe Wren Guest House
Guesthouse in North Charleston
4.93 out of 5 average rating, 377 reviewsCozy Park Circle, Charleston Guest House
Guesthouse in Columbia
5 out of 5 average rating, 398 reviewsCozy studio apartment, convenient location
Guesthouse in Donalds
4.99 out of 5 average rating, 358 reviewsHome on the farm
Guesthouse in Pendleton
4.89 out of 5 average rating, 251 reviewsLa Bella Farm
Guest house rentals with a patio
Guesthouse in Charleston
4.79 out of 5 average rating, 138 reviewsGuest Suite by the Beach
Guesthouse in Travelers Rest
4.98 out of 5 average rating, 107 reviewsModern guesthouse in downtown TR
Guesthouse in Greenville
4.95 out of 5 average rating, 139 reviewsCozy Downtown GVL Studio
Guesthouse in Greenville
4.98 out of 5 average rating, 109 reviewsFinished Room over Garage (FROG) on Reedy River
Guesthouse in Charleston
4.99 out of 5 average rating, 118 reviewsThe James: “Tiny” Home b/w Downtown & Folly
Guesthouse in Johns Island
4.89 out of 5 average rating, 147 reviewsCozy Cottage! 5 mins from Kiawah!
Guesthouse in Abbeville
4.96 out of 5 average rating, 132 reviews1-bedroom guesthouse in Abbeville, SC
Guesthouse in North Charleston
5 out of 5 average rating, 139 reviewsThe Park Circle Clerestory Studio Guest House
Guest house rentals with a washer and dryer
Guesthouse in Columbia
4.89 out of 5 average rating, 385 reviewsCozy retreat near Williams Brice/Ft. Jackson/UofSC
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 140 reviewsBeach, downtown, Alhambra Hall weddings so close!
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 238 reviewsCozy Apartment in Mount Pleasant
Guesthouse in Six Mile
4.9 out of 5 average rating, 110 reviewsCamper at Hickory Lodge and Guesthouse
Guesthouse in Lyman
4.99 out of 5 average rating, 144 reviewsBlue Heron Hideaway Lakeside Retreat
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 446 reviewsGuesthouse Convenient to Charleston, Shem Creek, and Beaches
Guesthouse in Columbia
4.92 out of 5 average rating, 125 reviewsBrand New Studio Guest House with Full Kitchen.
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 479 reviewsOld Mt. Pleasant/Shem Creek close to Sullivans/DT
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