Family-friendly vacation rentals in Santee

Find and book unique family-friendly homes on Airbnb

Top-rated family-friendly rentals in Santee

Guests agree: these family-friendly homes are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Kensington

4.97 out of 5 average rating, 549 reviews

Central & Serene Secret Garden Guesthouse

My cozy & stylish Garden Guesthouse features colorful decor that gives a fun, relaxed vibe. Relax in style inside or outside in my peaceful garden w a cup of coffee, or glass of wine. I love to say a hi to my guests yet your privacy is #1. Reach me via Airbnb app if I can help! Kensington is a central, 1920’s historic neighborhood w shops & great local eateries. Close to downtown, Gaslamp, Zoo, airport, beaches, Balboa Park. Bus stop, & trolley nearby. Reserved off street parking space too!

Guest favorite

Guesthouse in La Mesa

4.93 out of 5 average rating, 228 reviews

Fig Tree Bungalow

Enjoy your stay in San Diego in this newly renovated guesthouse. Centrally located about a mile from Hwy 8, Hwy 125, and the Grossmont Trolley Station & Transit Center. Only a 15-20 minute drive to downtown, the airport, the beaches, and most of San Diego's other popular tourist attractions. This cozy, two-story, detached unit is located behind my home, and has its own private entrance and partitioned yard for your enjoyment. There's plenty of street parking directly in front of the house.

Guest favorite

Guest suite in San Diego

4.98 out of 5 average rating, 449 reviews

Super clean & private studio retreat.

We call our place Casita Pacifica (Peaceful Little House) as this suite is a mellow and relaxing retreat, yet in a San Diego suburb only 10-20 minutes from everything. Sadly, we no longer host peacocks, but our space is decorated in memory of their majestic energy. Our standards are high when we travel, so we created a suite that we'd love to stay in ourselves: stocked with goodies, things to do, recommendations, privacy, comfort & above all - cleanliness. WE FOLLOW CDC CLEANING GUIDELINES.

Guest favorite

Guesthouse in La Mesa

4.93 out of 5 average rating, 154 reviews

Granny Flat with Bedroom/Bathroom/Kitchen

My place is family friendly, close to comic con, , restaurants and dining, , the beach, , family-friendly activities , public transportation (trolley). You’ll love my place because of the peace and quiet. It's very quiet and private. PLEASE DO NOT BOOK IF YOU ARE PLANNING ON PARTYING. THIS IS NOT APPROPRIATE FOR MORE THAN 2 PEOPLE. There is a private entrance that you may use once you meet us.. We like to meet all our guests first and then you may come and go as needed. NO SMOKING NO PETS

Guest favorite

Guesthouse in San Diego

4.97 out of 5 average rating, 321 reviews

Private Guest House with a View

A charming, detached guest house located centrally in San Diego, Ca. Guest house is located on a hill with views of the canyon. Get full access to your own kitchen with coffee & tea amenities. Wifi access. Smart TV access to Netflix, Prime Video, Disney+, Hulu, etc.. Comfortable queen bed with a full size sofa pullout bed that can accommodate up to 4 guests. Clean and spacious backyard that you can relax and unwind in. 80’ leveled driveway 12’ wide is big enough to accommodate any RV.

Guest favorite

Home in La Mesa

4.96 out of 5 average rating, 508 reviews

Clean 1BR/1BA Guest House Peaceful Private Casita

Discover the perfect home away from home in San Diego! Our cozy and tranquil guest house is located just a short drive from the city's top attractions, including the San Diego Zoo and beautiful beaches. Relax and unwind in the comfortable living room and enjoy all the amenities you need for a peaceful stay. With a comfortable queen-sized bed, full kitchen, and fresh towels, you'll have everything you need to feel at home. Book your stay with us today and experience the best of San Diego!

Guest favorite

Rental unit in Serra Mesa

4.98 out of 5 average rating, 426 reviews

Lovely spacious upstairs studio with private entry

You’ll love our place as its spacious, quiet, private, comfortable in a residential neighborhood. The king-size bed is extremely comfortable and we have big relaxing patio chairs on our large balcony overlooking a beautiful landscaped garden. We are centrally located to most all of San Diego's attractions and close to freeways. The famous Gaslamp, Zoo, downtown and beaches are all within 13 to 20 minute drive. The kitchen is stocked with goodies, coffee and an assortment of teas.

Guest favorite

Guesthouse in El Cajon

4.98 out of 5 average rating, 206 reviews

Fletcher Hills - modern 1 BR.Easy, no step access.

** 48 hours between check-ins. Thorough cleaning and sanitizing.. Four night minimum stay. Dogs ONLY are welcomed on a case by case basis. They must be house trained and are not permitted on any furniture. If you instant book, you must contact me about your pet within 24 hours. Smoking is permitted in the outside areas - patio, gazebo, yard. Easy freeway access helps any commute to downtown and area attractions. Having your own vehicle is the best way to get around..

Guest favorite

Guesthouse in Dulzura

4.97 out of 5 average rating, 605 reviews

Vineyard & Winery Guest House

A hidden gem! Get away and stay at the historic pioneer era Clark Ranch established in 1885. Our guest house sits above our winery tasting room and has its own private entrance and driveway. It's clean, cozy, and self-contained . Make it a weekend 'getaway' stay and sample our fine wines , and Estate Olive Oil. There is a tower in the vineyard where you can enjoy a glass of wine and watch the sun set. Balcony overlooks Dulzura Creek.

Guest favorite

Cottage in La Mesa

4.96 out of 5 average rating, 298 reviews

La Mesa House On a Hill With Mountain Views!

SUNRISE PERCH - A standalone guest house, perfect spot for your San Diego stay! Enjoy inspiring sunrise views from the deck or relax indoors with super fast WiFi and a 43" TV. Enjoy a full kitchen! The king bed is super comfy and the bathroom is stocked. The space is only for those looking for quiet. No partying/loud socializing. Families welcome! Located 20 min from downtown San Diego and 25 min from the nearest beach (Ocean Beach).

Guest favorite

Guesthouse in Chula Vista

4.95 out of 5 average rating, 518 reviews

Private Casita in Great Eastlake Neighborhood

This room is a "casita" (seperate living space) away from the house. It has a private entrance with a cypher lock on the door. The room has new carpet, new tile, and queen size bed. The Eastlake neighborhood is very safe and very quiet. We are located about 20 mins from the beach, downtown San Diego, and San Diego international airport. This location is only 2 miles from the Otay Ranch Mall.

Guest favorite

Guesthouse in Allied Gardens

4.95 out of 5 average rating, 368 reviews

The BEST NEST Clean, peaceful, private, affordable

This lovely private & separate unit is comfortable, clean and convenient. Your completely private suite is accessible via your own entrance. Minutes from major attractions, away from the hustle and bustle. Full kitchen for easy meal preparation. Located in a nice usually quiet neighborhood, close to major freeways. Enjoy the gorgeous San Diego weather in the quaint outdoor patio area.