House vacation rentals in Santee

Find and book unique houses on Airbnb

Top-rated house rentals in Santee

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Alpine

4.99 out of 5 average rating, 173 reviews

Fully Fenced Alpine Property with Guest House

Our guest house is located in the back of our personal property & kept private by fencing. Our property is fully fenced & guests have access in & out by using a keypad. We have laundry facilities, a queen size bed in the master bedroom, a sofa sleeper in the living room/kitchen area and a private patio with bbq. We occupy the main home on the property. We have 2 dogs on the property so other animals are not recommended at this location. Children swing set/tramploine not included with Airbnb.

Superhost

Home in La Mesa

4.83 out of 5 average rating, 148 reviews

La Mesa's Tranquility

We invite you to relax at our quiet and family-friendly home. Enjoy a perfect climate after a day at the beach, work, or San Diego's attractions. Located 10-15 minutes away from most of San Diego's attractions and the Airport. House offers a spacious well-equipped kitchen and a large living room with an artificial fireplace. You can have a small celebration as long as you inform us and get our approval to host your event. There is a front patio for outdoor relaxation and a three-burner grill.

Superhost

Home in La Mesa

4.86 out of 5 average rating, 206 reviews

Newer "Manor Studio"

Centrally located in San Diego County this brand new studio style unit has a private entrance, private patio area and street parking. Furnished with a queen size bed, love seat, full bathroom and kitchen area. One large drawer to accommodate personal items, and a wall rack to hang clothing. There is a smart TV with WiFi streaming capabilities and lots of USB plugs to charge your devices. On street parking in front of unit (no parking in driveway). No Pets allowed. No Hair Dying allowed.

Guest favorite

Home in La Mesa

4.98 out of 5 average rating, 292 reviews

Travel Writer's Pad

Hello, Bonjour, Hola, Ciao, Ni Hao! For the past two decades my career as a travel journalist has taken me around the globe. I’ve stayed at thousands of accommodations, where I learned personal touches create a comfortable home away from home. Certain places I visited offered extra special amenities, such as Green tea at a Japanese Ryokan & chardonnay infused bath salts at a Mexican posada. These kinds of touches are in the home. I welcome you, but no parties or events at the house. Thanks!

Guest favorite

Home in La Mesa

4.96 out of 5 average rating, 508 reviews

Clean 1BR/1BA Guest House Peaceful Private Casita

Discover the perfect home away from home in San Diego! Our cozy and tranquil guest house is located just a short drive from the city's top attractions, including the San Diego Zoo and beautiful beaches. Relax and unwind in the comfortable living room and enjoy all the amenities you need for a peaceful stay. With a comfortable queen-sized bed, full kitchen, and fresh towels, you'll have everything you need to feel at home. Book your stay with us today and experience the best of San Diego!

Guest favorite

Home in La Mesa

4.93 out of 5 average rating, 203 reviews

Cottage in the Garden! New! Modern!

COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

Guest favorite

Home in La Mesa

4.99 out of 5 average rating, 188 reviews

SDCannaBnB #2 *420 *parking *dog-friendly *hot tub

Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our studio is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our studio has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our studio is located in our quiet, fully fenced in backyard, close to San Diego's attractions

Guest favorite

Home in Lakeside

4.93 out of 5 average rating, 132 reviews

The Hills Oasis Pool, Jacuzzi & Pickleball

SEND US A MESSAGE FOR SPECIAL OFFER! Imagine booking the most memorable experience with your party! Kick back and relax in a safe stylish, family and friend oriented experience! Check in contactless and enjoy! Cozy, modern and includes an outdoor fire pit, spa, and pickle ball! With the whole house comes parking up to 6 cars, 2 bathrooms (1 is ADA compliant), and an alluring kitchen. The entire house is 30 minutes from the beach, 45 to the snow, and 30 minutes from downtown San Diego.

Guest favorite

Home in San Carlos

4.94 out of 5 average rating, 421 reviews

Spacious home with incredible backyard views

This beautifully appointed home is located in a quiet neighborhood & is central to all San Diego attractions - 5 min to hiking, 15 min to beaches/Zoo/Sea World, 20 min to downtown & 35 min to Legoland. But should you chose to stay in to relax there's plenty to enjoy - Bocce Ball, hot tub, BBQ & gas fire pit. Perfect for families or small groups looking to enjoy San Diego. Please note, if you’re looking to have a party or gathering this is NOT the property for you.

Guest favorite

Home in El Cajon

4.97 out of 5 average rating, 112 reviews

Top hills, luxury, Sunset View, 4 BR, Pool/Spa

A luxury, house with private entrance and saltwater pool/jacuzzi Located in Fletcher Hills,Ca house located on a hill with the views of mountains and San Diego city. Enjoy this fully and luxuriously furnished 4 bedroom, 2 full bath,Get full access to your own kitchen with all the amenities. Wifi access. Smart TV access to Netflix.This house is good for couples, business travelers, and families with kids! It's cozy, comfy, and feel right at home.

Guest favorite

Home in El Cajon

4.97 out of 5 average rating, 143 reviews

Beautiful 3,000 Sq Ft Tropical Oasis

Beautiful 4 Bedroom, 2 1/2 Bath Family Home Located in Tranquil Fletcher Hills. This 3,000 sq. ft. Home is Perfect for large families who wish to Relax in a Peaceful Setting. 24-hour self check-in keypad after 4pm and check-out at 11AM. Host does not allow parties/events. This is NOT a Party House! This home is located in a quiet residential neighborhood, Guests who do not respect this will be asked to leave.

Guest favorite

Home in El Cajon

4.97 out of 5 average rating, 116 reviews

Suite Charles Way: A Cozy Fletcher Hills Studio

This newly remodeled spacious studio retreat features a private courtyard with barbecue, kitchenette, a brand-new California King bed, and a reclining love seat with charging ports. Enjoy a relaxed cabana vibe, a charming neighborhood and treetop views with easy access to all your favorite San Diego destinations. Within minutes from Grossmont Sharp Hospital, Grossmont Center, the trolley and Grossmont College.