Family-friendly vacation rentals in Cape Girardeau

Find and book unique family-friendly homes on Airbnb

Top-rated family-friendly rentals in Cape Girardeau

Guests agree: these family-friendly homes are highly rated for location, cleanliness, and more.

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Guest favorite

Cabin in Murphysboro

4.94 out of 5 average rating, 105 reviews

Lakefront Woodland Wonderland—Shawnee NF—ILOzarks

The only lakefront rental on Kinkaid's sparkling waters, this respite is steeped in serenity & surrounded by nature's wonders. Floor-to-ceiling windows & covered balcony across entire width of home create magnificent overlook of grounds—including woods, creek, bluff, & large waterfront yard. The night skies are dense, laughs belly-full, sunsets resplendent, & wildlife abundant. Bring a kayak, boat, or just yourself for a getaway where bluff-top breezes distill into deep breaths of contentment.

Guest favorite

Home in Carbondale

5 out of 5 average rating, 553 reviews

Charming 3 bedroom bungalow in Downtown Carbondale

Originally built in 1920, this cute bungalow house has been totally renovated and modernized. You'll enjoy 3 furnished bedrooms, 1 bathroom, covered porch, and back with lighted pergola and firepit. The location is exceptional - just two blocks North of the Carbondale downtown "strip," and EASILY walkable to all the downtown businesses, Memorial Hospital of Carbondale (0.4 miles), restaurants, pubs, Amtrak station (0.5 miles), and SIU (about 1.2 miles). Officially Permitted Airbnb VRU 23-03

Guest favorite

Loft in Perryville

4.97 out of 5 average rating, 301 reviews

Downtown Loft Amazing Bath Tub & Shower

Downtown Perryville, MO **DISCLAIMER** you will hear restaurant chatter & music if you do not have a tv/or radio playing between the hours of 10:30am & 1:30am. If you go to bed early I recommend headphones, ear plugs or play nature sounds on Alexa. This is a pet friendly loft apartment so I would not recommend if you are allergic to dogs or cats. This apartment is located above one of the most popular destination restaurant's around "Mary Jane Burgers & Brew" on the Downtown Historic Square.

Guest favorite

Home in Tunnel Hill

5 out of 5 average rating, 287 reviews

Pole Barn Cabin Lake of Egypt ~ Hottub Wineries

Located at Lake of Egypt, Tunnel Hill, IL in the Shawnee National Forest. Come enjoy our modern pole barn cabin with a hot tub. It is 600 sq ft, 2BR, 1BA, loft area, completely furnished with W/D, big flat screen TV, coffee bar, memory foam mattresses. New Blackstone! There is an association dock area which will require a waiver for a dock on the lake with kayaks. Come enjoy a weekend on the water or visit nearby Shawnee Wine Trail, Ferne Clyffe State Park, hunting, fishing and much more.

Guest favorite

Guesthouse in Cape Girardeau

4.93 out of 5 average rating, 476 reviews

Downtown Guesthouse- Romantic Getaway

The guesthouse seamlessly blends modern amenities with historic charm in a cozy, compact space. The antique claw foot tub/shower combo offers a charming, yet snug, spot for a relaxing soak—true to its historic roots, the bathroom could be best described as a quaint water closet. After a day of exploring unwind in the patio. Play a favorite record, and savor your coffee while daydreaming about new experiences. Despite its small size, it provides all the modern comforts you need.

Guest favorite

Guesthouse in Carbondale

4.99 out of 5 average rating, 240 reviews

Carbondale Pool House - Sauna, Hot Tub, Dogs OK

Rated in “Top 1%” by Airbnb, the Pool House is a separate cottage surrounded by gardens and swimming pool, with retro "Danish Modern" furniture, a gourmet kitchen and plush beds. We have recently added a Finnish Sauna and Japanese Ofuro Soaking Tub. We accept well behaved dogs for a fee of $35 a night. We allow only guests and friends of the Pool House on the grounds, gardens or pool. Hosts are Jane, anthropologist and D. a retired photojournalist for the New York Times.

Guest favorite

Cabin in Pomona

4.95 out of 5 average rating, 199 reviews

New Kitchen! Cozy Cabin on the SI Wine Trail!

What makes The Loft truly unique is its location. At the start of the S.I. Wine Trail, the cabin is just minutes to Cedar Lake, 15 minutes from nationally award winning BBQ, delicious ice cream, shopping, and fun of all sorts! On a 70 acre organic farm, the cabin is tucked into a breathtaking valley next to the Shawnee National Forest and has a gourmet kitchen and is filled with antiques, original eclectic artwork, plus toddler gear so you can travel light! You’ll love it!

Guest favorite

Cabin in Ozark

4.97 out of 5 average rating, 176 reviews

Whispering Pines Cabins & Outfitting-Pine Tree

Charming, luxury cabin in the pines fit for families, friends, and couples. Picturesque setting on a 196 acre property with 8 ponds next to rows of pine trees and green for miles. Relax at the cabin, or get out for some fun at all the local wineries/breweries, state/national parks, forest zip lining, hiking, and more. Southern Illinois is the perfect place to get away for the weekend, unplug, and connect with nature.

Guest favorite

Home in Carterville

4.92 out of 5 average rating, 314 reviews

Newly Updated Family Home in Carterville

This cozy 3 bedroom 2 bath house can easily house your family on your future trip to Southern Illinois. The home is conveniently located within a short drive of Marion, Carbondale and the Wine Trail. We look forward to hosting you on your future visit. We are currently updating the house regularly between bookings, the furniture and fixtures may change for the better between the time of booking and your stay.

Superhost

Cabin in Goreville

4.9 out of 5 average rating, 216 reviews

Red Roof Retreat Cabin

Log cabin rental with lake view at Lake of Egypt in southern IL with 2 lofts. Sleeps 4-6. Canoe, kayak, paddleboat, fishing poles and 2 mountain bikes available with rental. Dock available for your boat. Full kitchen with dishes, utensils, pots and pans and a few treats. All linens (towels, sheets, blankets) included. Grill and firepit. Fireplace for cozy winter. Outdoor deck and view of the night sky to die for.

Guest favorite

Home in Cape Girardeau

4.98 out of 5 average rating, 389 reviews

The Hamilton House

Majestic, Two Story Home. A Great Place for Making Memories. BEFORE YOU BOOK: So there are no misunderstandings. Please read our rules, and understand our pricing, because there is an extra guest fee after the first 2 guests and weekends are priced different than weekdays. 2 Night Min. Stay on Weekends Only - 1 Night Stays Sun. - Thurs. No Parties-No Smoking-No Animals

Guest favorite

Tiny home in Marion

4.96 out of 5 average rating, 241 reviews

Paddle Boards for Water + Near Hiking & Wineries

Have you ever wondered what it would be like to stay in a micro cabin or tiny house? Our cabin is a spacious tiny home at 560 sq ft. You'll love the modern appeal, ample natural light & views overlooking our 1.5-acre pond. Pet Friendly and minutes from Lake of Egypt, hiking & wineries. The swimmable pond is stocked with bass and bluegill with a few catfish and Koi.