House vacation rentals in Cape Girardeau

Find and book unique houses on Airbnb

Top-rated house rentals in Cape Girardeau

Guests agree: these houses are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Home in Marion

4.98 out of 5 average rating, 117 reviews

⭐️ SO. ILLINOIS Newly Built Coffee Bean house! ⭐️

It’s always a brew-ti-ful day at the NEW 2BR Coffee Bean. Guests can’t wait to rise & grind over to the coffee bar where you can pick out a Rae Dunn mug based on your current mood & add a flavored syrup, if you’re feeling fancy. A few perks include; washer/dryer for guest use, office area, smart tv, king bed, walk-in closets, dishwasher, dining area, comfy sectional. The Coffee Bean is the perfect blend of cozy furnishings, soft linens & convenient location to downtown Marion/ Route 13 & I-57..

Guest favorite

Home in Carbondale

5 out of 5 average rating, 553 reviews

Charming 3 bedroom bungalow in Downtown Carbondale

Originally built in 1920, this cute bungalow house has been totally renovated and modernized. You'll enjoy 3 furnished bedrooms, 1 bathroom, covered porch, and back with lighted pergola and firepit. The location is exceptional - just two blocks North of the Carbondale downtown "strip," and EASILY walkable to all the downtown businesses, Memorial Hospital of Carbondale (0.4 miles), restaurants, pubs, Amtrak station (0.5 miles), and SIU (about 1.2 miles). Officially Permitted Airbnb VRU 23-03

Guest favorite

Home in Tunnel Hill

5 out of 5 average rating, 287 reviews

Pole Barn Cabin Lake of Egypt ~ Hottub Wineries

Located at Lake of Egypt, Tunnel Hill, IL in the Shawnee National Forest. Come enjoy our modern pole barn cabin with a hot tub. It is 600 sq ft, 2BR, 1BA, loft area, completely furnished with W/D, big flat screen TV, coffee bar, memory foam mattresses. New Blackstone! There is an association dock area which will require a waiver for a dock on the lake with kayaks. Come enjoy a weekend on the water or visit nearby Shawnee Wine Trail, Ferne Clyffe State Park, hunting, fishing and much more.

Guest favorite

Home in Ste. Genevieve

4.94 out of 5 average rating, 139 reviews

"Little Brick House" (Hael House built in 1865)

Best downtown location!! Take a trip back in time at this cozy, centrally-located brick cottage in historic Ste. Genevieve. The original home of John and Francesca Hael in the 1860's, you won't find a more authentic old town experience than you will get at "the little brick house" on Main Street. Enjoy mornings at the local coffee shops and bakeries (right across the street) and evenings on the back porch with a glass of wine. The Little Brick House has all the amenities with old world charm!

Guest favorite

Home in Cape Girardeau

4.97 out of 5 average rating, 127 reviews

River Run

Charming 1940s farmhouse. Updated 1 1/2 story house in a rural setting overlooking the Mighty Mississippi River, but close to the heart of Cape Girardeau. Our house has lots of room to relax with a large kitchen and sunroom. You can sit by a cozy fire pit and enjoy chilly evenings watching the beautiful sunsets. We look forward to you spending time in our neck of the woods (so to speak). We are located with in seven miles from the Isle casino, SEMO state university and a happening down town.

Guest favorite

Home in Cape Girardeau

4.83 out of 5 average rating, 105 reviews

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

Guest favorite

Home in Ste. Genevieve

4.99 out of 5 average rating, 134 reviews

Silo Farm Haus

The Silo Farm Haus is a one of a kind grain silo custom designed into a beautiful, rustic home that sits on a 200 acre farm located in the heart of Sainte Genevieve wine country! The house has nearly 800 sq ft of a truly unique, round house experience. An upstairs, spacious loft features a queen size bed, & antique furniture. Downstairs has a full size eat-in kitchen, laundry room, bathroom and cozy living room. An air mattress is available to sleep 2 guests in the living room.

Guest favorite

Home in Jackson

4.92 out of 5 average rating, 301 reviews

The Rusty Owl-A Charming Victorian Dwelling

The Rusty Owl is a peaceful place with easy access to I-55. House has high speed (300 up and down) wifi. Jackson: Check out Flickerwood Arena, (9 minutes away... for ATV and barrel racing; horse shows and rodeos) Jackson History Center: Free. Open daily. Cape Girardeau downtown: Live music and relaxation at The Library, Casino, VFW and Eagles. 1 private lower level queen bedroom/ two private (1 queen, 1 twin) rooms and one room with a queen bed and a twin bed upstairs.

Guest favorite

Home in Cape Girardeau

4.86 out of 5 average rating, 118 reviews

Lucky King-4-bedroom Steps away from the casino

Directly across the street from Century Casino. This 4 Bedroom, 2 Bath home Sleeps 11 and is perfect for larger groups staying together. Completely remodeled with design touches that highlight all of Cape Girardeau's wonderful history. Three of the 4 bedrooms have king size beds. One bedroom offers one queen bed and one twin. In addition to 4 bedrooms, the living room features a pullout couch. Plenty of parking and in a very private location.

Guest favorite

Home in Dongola

4.96 out of 5 average rating, 141 reviews

Spacious Home in Country Setting

READ ENTIRE DESCRIPTION BEFORE BOOKING!!! Retreat in this spacious home, tucked into a quiet natural setting. The second story deck extends the full length of the front of the house, giving a lovely view of the peaceful surroundings. With no television or other technological distractions on the premises, this home is perfectly suitable for quality time with your loved ones and can accommodate large families.

Guest favorite

Home in Cape Girardeau

4.98 out of 5 average rating, 389 reviews

The Hamilton House

Majestic, Two Story Home. A Great Place for Making Memories. BEFORE YOU BOOK: So there are no misunderstandings. Please read our rules, and understand our pricing, because there is an extra guest fee after the first 2 guests and weekends are priced different than weekdays. 2 Night Min. Stay on Weekends Only - 1 Night Stays Sun. - Thurs. No Parties-No Smoking-No Animals

Guest favorite

Home in Marion

4.8 out of 5 average rating, 625 reviews

Frank Lloyd Wright design inspired house

PET FRIENDLY-Frank Lloyd Wright design. This home is Unique and spacious! It is conveniently located near interstate 57, and 12 minutes from the Lake of Egypt. It is also close to Shawnee Hills National Forest for beautiful hiking trails and picnics as well as 12 local wineries! After your adventures, Relax in the rustic outdoor area that provides plenty of privacy.