Mansion vacation rentals in Panama
Find and book unique mansions on Airbnb
Top-rated mansion rentals in Panama
Guests agree: these mansions are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama mansion rentals
Mansion rentals with a pool
Home in San Carlos
4.93 out of 5 average rating, 88 reviewsBeach House-Ocean View Rooftop Jacuzzi & Pool
Cottage in Altos del Maria
4.93 out of 5 average rating, 99 reviewsCabin with Spectacular Mountain View
Home in Playa Bluff
5.0 out of 5 average rating, 16 reviewsJungle House 100m from the beach
Condo in Maria Chiquita
5.0 out of 5 average rating, 19 reviewsPlaya Escondida Lux Beachfront Haven:Oceanview Apt
Villa in Portobelo
5.0 out of 5 average rating, 42 reviewsEntire Villa with pool in front of beach!
Home in Río Hato
4.95 out of 5 average rating, 75 reviewsSpectacular beachfront house in Buenaventura!
Villa in Playa Venao
4.98 out of 5 average rating, 61 reviewsCasa Aqua: Amazing beach front house - Playa Venao
Villa in Buenaventura, El Chirú
4.84 out of 5 average rating, 45 reviewsLake House | Pool | King Beds | Next to Beach Club
Luxury mansion rentals
Apartment in Maria Chiquita
4.95 out of 5 average rating, 21 reviewsPenthouse in Playa Escondida 4 bedrooms
Villa in Bejuco
4.96 out of 5 average rating, 78 reviewsBeach house in Punta Chame, Villa frente al mar
Apartment in Panama City
5.0 out of 5 average rating, 20 reviews24o Penthouse Unique Design 2 Balconies Oceanview
Apartment in Panama City
4.68 out of 5 average rating, 250 reviewsPenthouse with rooftop and pool 5 rooms Di5
Villa in Punta Chame
4.92 out of 5 average rating, 13 reviewsFREE NIGHT Amazing Beachfront Villa - Palm House
Apartment in El Chirú
4.94 out of 5 average rating, 85 reviewsBuenaventura Golf & Beach Resort Lux Apartment
Villa in Río Hato
4.91 out of 5 average rating, 22 reviewsSecluded Villa in Buenaventura Golf and Resort
Villa in Río Hato
4.92 out of 5 average rating, 73 reviews(Panama) Beach house with golf course.
Pet-friendly mansion rentals
Home in Gamboa
4.86 out of 5 average rating, 88 reviewsBirdHouse@ Gamboa Panamá Canal
Condo in San Carlos District
4.97 out of 5 average rating, 38 reviewsPunta Caelo Beach Front View
Home in San José
5.0 out of 5 average rating, 19 reviewsαlkeyler| Luxury Mini Resort 12 PERS @Punta Barco
Villa in Bocas del Toro
5.0 out of 5 average rating, 56 reviewsCasa del Mar - eco aqua villa
Villa in Costa Esmeralda
4.97 out of 5 average rating, 70 reviews#1 Villa with pool, jacuzzi, pool table, ping pong.
Villa in Costa Esmeralda
5.0 out of 5 average rating, 14 reviewsSpectacular 600-meter oceanfront beach house
Home in Panamá
5.0 out of 5 average rating, 9 reviewsWonderful House with Terrace and Sea View
Home in Río Hato
4.98 out of 5 average rating, 96 reviewsComplete House for a Perfect Stay
Destinations to explore
- Rentals with a fireplace Panama
- Rentals with beach access Panama
- Rentals with a patio Panama
- Boutique hotel rentals Panama
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- Chalet rentals Panama
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- Rentals with a sauna Panama
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- Monthly Rentals Panama
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- Nature eco lodge rentals Panama
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- Villa rentals Panama
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