Guesthouse vacation rentals in Upstate South Carolina
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Top-rated guesthouse rentals in Upstate South Carolina
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for Upstate South Carolina guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Townville
4.88 out of 5 average rating, 232 reviewsLisa’s Lodge
Guesthouse in Pendleton
4.89 out of 5 average rating, 243 reviewsLa Bella Farm
Guesthouse in Simpsonville
4.94 out of 5 average rating, 225 reviewsPrivate Suite in Downtown Simpsonville
Guesthouse in Saluda
4.98 out of 5 average rating, 255 reviewsCarolina Cottage Guest House
Guesthouse in Greer
4.94 out of 5 average rating, 245 reviewsExecutive Suite on a farm @GSP Airport
Guesthouse in Rutherfordton
4.96 out of 5 average rating, 225 reviewsTryon Foothills Getaway - NC Wineries - TIEC
Guesthouse in Lexington
4.94 out of 5 average rating, 249 reviewsCome Pause and Relax!
Guesthouse in Tryon
4.98 out of 5 average rating, 104 reviewsHistoric Jockey Cottage, TIEC 20 mins, Tryon 5
Guest house rentals with a patio
Guesthouse in Toccoa
4.99 out of 5 average rating, 111 reviewsCozy Rustic Lakefront Cabin
Guesthouse in Tryon
4.99 out of 5 average rating, 129 reviews1 bedroom guest house on horse property in Tryon
Guesthouse in Clarkesville
5.0 out of 5 average rating, 159 reviewsCozy guest cottage at The Black Walnut Chateau
Guesthouse in Watkinsville
4.99 out of 5 average rating, 123 reviewsDowntown guest house with private hot tub & deck
Guesthouse in Sylva
4.96 out of 5 average rating, 137 reviewsWindcrest Loft- charming retreat near the river.
Guesthouse in Asheville
4.96 out of 5 average rating, 147 reviewsFirefly Cove Guesthouse
Guesthouse in Arden
4.98 out of 5 average rating, 107 reviewsMountain Modern Asheville: Guest House
Guesthouse in Spartanburg
5.0 out of 5 average rating, 46 reviewsThe Lodge at Pythian Park
Guest house rentals with a washer and dryer
Guesthouse in Hartwell
4.98 out of 5 average rating, 134 reviewsGuest House at Lake Hartwell
Guesthouse in Tuckasegee
4.99 out of 5 average rating, 181 reviewsWolf Lake Escape - lake & mountain retreat
Guesthouse in Shelby
4.98 out of 5 average rating, 227 reviewsCabin in the Pines
Guesthouse in Greenville
4.96 out of 5 average rating, 183 reviewsThe Biltmore Suite
Guesthouse in Greenville
4.93 out of 5 average rating, 201 reviews“The Dogwood Cottage” near Greenville
Guesthouse in Hendersonville
5.0 out of 5 average rating, 174 reviewsWhite Squirrel Bungalow
Guesthouse in Tryon
4.95 out of 5 average rating, 144 reviewsHorse Haven - 1 Bedroom Loft 8 Miles to TIEC
Guesthouse in Toccoa
5.0 out of 5 average rating, 149 reviewsToccoa Guesthouse.
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